biostudies-literatureUnknown26(1)Hou H<h4>Background</h4>The high prevalence of recurrent depressive episodes (RDE) among patients with major depressive disorder (MDD) has resulted in substantial personal, societal, and financial burdens. Although many studies have explored the factors associated with RDE, most have important methodological limitations. This study aims to examine the factors associated with RDE within two years among young adults with first-episode MDD.<h4>Method</h4>A total of 324 patients aged 18 to 30 years with a first episode of MDD completed both the baseline assessment and the two-year follow-up. Personal, psychosocial, and illness-related variables were assessed at baseline. The status of RDE and medication use were evaluated at follow-up. Network analysis and logistic regression were performed to examBMC psychiatry46https://www.ebi.ac.uk/biostudies/studies/S-EPMC12809907biostudies-literatureDysfunctional attitude and childhood maltreatment predict future recurrence among young adults with first-onset depression: a prospective cohort study.PMC12809907Zhang WZou HMa SWang XQWang FYang BXHou HYang CKang LYu YLuo DfalseDysfunctional attitude and childhood maltreatment predict future recurrence among young adults with first-onset depression: a prospective cohort study.<h4>Background</h4>The high prevalence of recurrent depressive episodes (RDE) among patients with major depressive disorder (MDD) has resulted in substantial personal, societal, and financial burdens. Although many studies have explored the factors associated with RDE, most have important methodological limitations. This study aims to examine the factors associated with RDE within two years among young adults with first-episode MDD.<h4>Method</h4>A total of 324 patients aged 18 to 30 years with a first episode of MDD completed both the baseline assessment and the two-year follow-up. Personal, psychosocial, and illness-related variables were assessed at baseline. The status of RDE and medication use were evaluated at follow-up. Network analysis and logistic regression were performed to exam2025-01-01T00:00:00Z2025 Dec2026-06-12T05:07:22.333Z2026-06-12T03:07:51.037ZS-EPMC128099074138838810.1186/s12888-025-07579-5