{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Posset R"],"funding":["Intellectual and Developmental Disabilities Research Center","National Center for Advancing Translational Sciences","Eunice Kennedy Shriver National Institute of Child Health and Human Development","NICHD NIH HHS","Kettering Fund","National Institute of Diabetes and Digestive and Kidney Diseases","National Institutes of Health","European Commission"],"pagination":["108112"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12812261"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["141(3)"],"pubmed_abstract":["<h4>Objective</h4>Liver transplantation (LTx) is an intervention when medical management is not sufficiently preventing individuals with urea cycle disorders (UCDs) from the occurrence of hyperammonemic events. Supplementation with L-citrulline/arginine is regularly performed prior to LTx to support ureagenesis and is often continued after the intervention. However, systematic studies assessing the impact of long-term L-citrulline/arginine supplementation in individuals who have undergone LTx is lacking to date.<h4>Methods</h4>Using longitudinal data collected systematically, a comparative analysis was carried out by studying the effects of long-term L-citrulline/arginine supplementation vs. no supplementation on health-related outcome parameters (i.e., anthropometric, neurological, and co"],"journal":["Molecular genetics and metabolism"],"pubmed_title":["Impact of supplementation with L-citrulline/arginine after liver transplantation in individuals with Urea Cycle Disorders."],"pmcid":["PMC12812261"],"funding_grant_id":["U54HD090257","P50 HD103555","U54HD061221","U54 HD090257","U54 HD061221"],"pubmed_authors":["Harding CO","Schulze A","Seminara J","Lam C","Coughlin CR","Stricker T","Kolker S","Urea Cycle Disorders Consortium (UCDC) and the European registry and network for Intoxication type Metabolic Diseases (E-IMD) consortia study group","Konczal L","Burrage LC","Gallagher RC","Breilyn M","Gleich F","Hoffmann GF","Ficicioglu C","Wong D","Garbade SF","Berry SA","Druck AC","Posset R","Ramdhouni N","Zielonka M","Mew NA","Gropman AL","Garcia-Cazorla A","McCandless SE","Dobbelaere D","Lawrence Merritt J","Lindner M","Epp F","Baumgartner MR","Nagamani SCS","Le Mons C","Wilkening G","Enns GM","Berry GT","Diaz GA"],"additional_accession":[]},"is_claimable":false,"name":"Impact of supplementation with L-citrulline/arginine after liver transplantation in individuals with Urea Cycle Disorders.","description":"<h4>Objective</h4>Liver transplantation (LTx) is an intervention when medical management is not sufficiently preventing individuals with urea cycle disorders (UCDs) from the occurrence of hyperammonemic events. Supplementation with L-citrulline/arginine is regularly performed prior to LTx to support ureagenesis and is often continued after the intervention. However, systematic studies assessing the impact of long-term L-citrulline/arginine supplementation in individuals who have undergone LTx is lacking to date.<h4>Methods</h4>Using longitudinal data collected systematically, a comparative analysis was carried out by studying the effects of long-term L-citrulline/arginine supplementation vs. no supplementation on health-related outcome parameters (i.e., anthropometric, neurological, and co","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-06-06T15:57:38.17Z","creation":"2026-06-02T03:10:42.266Z"},"accession":"S-EPMC12812261","cross_references":{"pubmed":["38301530"],"doi":["10.1016/j.ymgme.2023.108112"]}}