{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jung SH"],"funding":["Otoki Ham Taiho Foundation"],"pagination":["3937"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12813636"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(24)"],"pubmed_abstract":["<h4>Background</h4>Postbiotics produced by kefir lactic acid bacteria through bioconversion of polyphenol-rich extract and whey protein are emerging as promising modulators of gut microbiota and muscle health. This study investigated whether <i>Lentilactobacillus kefiri</i> DH5-derived postbiotics, prepared with <i>Cucumis melo</i> L. and whey protein (KP, Kefir lactic acid bacteria-derived postbiotics), improve muscle strength and gut microbiota composition in healthy adults.<h4>Methods</h4>In this 12-week, randomized, double-blind, placebo-controlled trial, participants consumed either KP (6 g/day) or placebo. Handgrip strength, circulating biomarkers, and fecal microbiota profiling (using 16S rRNA sequencing) were analyzed. Correlations between microbial taxa and muscle-related biomarkers were assessed.<h4>Results</h4>KP supplementation significantly increased dominant-hand grip strength and plasma irisin and reduced IL-1β concentrations after 12 weeks, whereas IGF-1, lean mass, and non-dominant grip strength showed no significant changes. Gut microbiota profiling revealed enrichment of <i>Bifidobacterium adolescentis</i>, <i>Latilactobacillus sakei</i>, <i>Lentihominibacter hominis</i>, <i>Mediterraneibacter gnavus</i>, <i>Streptococcus anginosus</i> and <i>Phocaeicola plebeius</i>, with concomitant reductions in <i>Lachnospira eligens</i>, <i>Roseburia inulinivorans</i>, <i>Ruthenibacterium lactatiformans</i> and <i>Vescimonas fastidiosa</i>. Notably, relative abundance of <i>Faecalibacterium prausnitzii</i> was positively correlated with plasma irisin concentration.<h4>Conclusions</h4>KP supplementation produced a modest within-group improvement in grip strength, potentially through gut-muscle axis modulation involving irisin and anti-inflammation pathways. These preliminary findings suggest that kefir-derived postbiotics may have potential relevance for muscle health."],"journal":["Nutrients"],"pubmed_title":["Bioconversion-Based Postbiotics Enhance Muscle Strength and Modulate Gut Microbiota in Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial."],"pmcid":["PMC12813636"],"funding_grant_id":["Otoki Ham Taiho Foundation"],"pubmed_authors":["Jung SH","Park Y","Seo KH","Hwang S","Kim H","Kim MJ"],"additional_accession":[]},"is_claimable":false,"name":"Bioconversion-Based Postbiotics Enhance Muscle Strength and Modulate Gut Microbiota in Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial.","description":"<h4>Background</h4>Postbiotics produced by kefir lactic acid bacteria through bioconversion of polyphenol-rich extract and whey protein are emerging as promising modulators of gut microbiota and muscle health. This study investigated whether <i>Lentilactobacillus kefiri</i> DH5-derived postbiotics, prepared with <i>Cucumis melo</i> L. and whey protein (KP, Kefir lactic acid bacteria-derived postbiotics), improve muscle strength and gut microbiota composition in healthy adults.<h4>Methods</h4>In this 12-week, randomized, double-blind, placebo-controlled trial, participants consumed either KP (6 g/day) or placebo. Handgrip strength, circulating biomarkers, and fecal microbiota profiling (using 16S rRNA sequencing) were analyzed. Correlations between microbial taxa and muscle-related biomarkers were assessed.<h4>Results</h4>KP supplementation significantly increased dominant-hand grip strength and plasma irisin and reduced IL-1β concentrations after 12 weeks, whereas IGF-1, lean mass, and non-dominant grip strength showed no significant changes. Gut microbiota profiling revealed enrichment of <i>Bifidobacterium adolescentis</i>, <i>Latilactobacillus sakei</i>, <i>Lentihominibacter hominis</i>, <i>Mediterraneibacter gnavus</i>, <i>Streptococcus anginosus</i> and <i>Phocaeicola plebeius</i>, with concomitant reductions in <i>Lachnospira eligens</i>, <i>Roseburia inulinivorans</i>, <i>Ruthenibacterium lactatiformans</i> and <i>Vescimonas fastidiosa</i>. Notably, relative abundance of <i>Faecalibacterium prausnitzii</i> was positively correlated with plasma irisin concentration.<h4>Conclusions</h4>KP supplementation produced a modest within-group improvement in grip strength, potentially through gut-muscle axis modulation involving irisin and anti-inflammation pathways. These preliminary findings suggest that kefir-derived postbiotics may have potential relevance for muscle health.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-03T03:16:45.432Z","creation":"2026-06-03T03:10:50.88Z"},"accession":"S-EPMC12813636","cross_references":{"pubmed":["41470885"],"doi":["10.3390/nu17243937"]}}