{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nielsen JC"],"funding":["Francis Crick Institute","Cancer Research UK","Horizon 2020 Framework Programme","Medical Research Council","Wellcome Trust"],"pagination":["jcs264444"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12813672"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["138(24)"],"pubmed_abstract":["Serum response factor (SRF) and its cofactors, myocardin-related transcription factors A and B (MRTF-A and MRTF-B, respectively), regulate transcription of numerous cytoskeletal structural and regulatory genes, and most MRTF/SRF inactivation phenotypes reflect deficits in cytoskeletal dynamics. We show that MRTF-SRF activity is required for effective proliferation of both primary and immortalised fibroblast and epithelial cells. Cells lacking the MRTFs or SRF proliferate very slowly, express elevated levels of senescence-associated secretory phenotype (SASP) factors and senescence-associated β-galactosidase activity, and inhibit proliferation of co-cultured primary wild-type cells. They exhibit decreased levels of CDK1 and CKS2 proteins, and elevated levels of CDK inhibitors, usually p27 ("],"journal":["Journal of cell science"],"pubmed_title":["MRTF-dependent cytoskeletal dynamics drive efficient cell cycle progression."],"pmcid":["PMC12813672"],"funding_grant_id":["897131","CC2102"],"pubmed_authors":["Benito-Jardon M","Nielsen JC","Treisman R","Christo Petrela N","Bellamy S","Diring J"],"additional_accession":[]},"is_claimable":false,"name":"MRTF-dependent cytoskeletal dynamics drive efficient cell cycle progression.","description":"Serum response factor (SRF) and its cofactors, myocardin-related transcription factors A and B (MRTF-A and MRTF-B, respectively), regulate transcription of numerous cytoskeletal structural and regulatory genes, and most MRTF/SRF inactivation phenotypes reflect deficits in cytoskeletal dynamics. We show that MRTF-SRF activity is required for effective proliferation of both primary and immortalised fibroblast and epithelial cells. Cells lacking the MRTFs or SRF proliferate very slowly, express elevated levels of senescence-associated secretory phenotype (SASP) factors and senescence-associated β-galactosidase activity, and inhibit proliferation of co-cultured primary wild-type cells. They exhibit decreased levels of CDK1 and CKS2 proteins, and elevated levels of CDK inhibitors, usually p27 (","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-13T04:53:08.339Z","creation":"2026-06-13T03:08:34.047Z"},"accession":"S-EPMC12813672","cross_references":{"pubmed":["41200793"],"doi":["10.1242/jcs.264444"]}}