{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jaime M"],"funding":["Agencia Nacional de Investigación y Desarrollo"],"pagination":["3"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12814593"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["59(1)"],"pubmed_abstract":["<h4>Background</h4>Rheumatoid Arthritis (RA) is an autoimmune disease in which HLA-DRB1 alleles encoding the \"Shared Epitope\" (SE), located in the β-chain of class II HLA-DR molecules, constitute the main genetic risk factor. However, there is scarce information about the role of HLA class I genes (HLA-ABC) in RA susceptibility. The present work aimed to evaluate the distribution of HLA-ABC allele groups in a cohort of Chilean RA patients and healthy subjects (HS), and to explore the influence of HLA-DRB1 SE alleles on this distribution.<h4>Results</h4>135 RA patients and 122 HS were genotyped for HLA-ABC. The most frequent allele groups were HLA-A*02 (24.0%), HLA-B*39.1 (14.2%), and HLA-C*07 (24.7%) for RA patients, and HLA-A*02 (31.5%), HLA-A*24 (12.8%) and HLA-C*07 (17.7%) for HS. RA pa"],"journal":["Biological research"],"pubmed_title":["Distribution of HLA-ABC allele groups in a cohort of Chilean rheumatoid arthritis patients and healthy individuals."],"pmcid":["PMC12814593"],"funding_grant_id":["1240060","1221611"],"pubmed_authors":["Catalan D","Montano-Bruno D","Bozan F","Toro L","Neira O","Pesce B","Cuellar-Gutierrez MC","Rivera G","Schneider D","Soto L","Arroyo C","Palou E","Jaime M","Aguillon JC","Varela-Villarroel C","Maggi J"],"additional_accession":[]},"is_claimable":false,"name":"Distribution of HLA-ABC allele groups in a cohort of Chilean rheumatoid arthritis patients and healthy individuals.","description":"<h4>Background</h4>Rheumatoid Arthritis (RA) is an autoimmune disease in which HLA-DRB1 alleles encoding the \"Shared Epitope\" (SE), located in the β-chain of class II HLA-DR molecules, constitute the main genetic risk factor. However, there is scarce information about the role of HLA class I genes (HLA-ABC) in RA susceptibility. The present work aimed to evaluate the distribution of HLA-ABC allele groups in a cohort of Chilean RA patients and healthy subjects (HS), and to explore the influence of HLA-DRB1 SE alleles on this distribution.<h4>Results</h4>135 RA patients and 122 HS were genotyped for HLA-ABC. The most frequent allele groups were HLA-A*02 (24.0%), HLA-B*39.1 (14.2%), and HLA-C*07 (24.7%) for RA patients, and HLA-A*02 (31.5%), HLA-A*24 (12.8%) and HLA-C*07 (17.7%) for HS. RA pa","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T15:03:07.928Z","creation":"2026-06-01T03:10:50.922Z"},"accession":"S-EPMC12814593","cross_references":{"pubmed":["41444678"],"doi":["10.1186/s40659-025-00663-w"]}}