biostudies-literatureJaime MAgencia Nacional de Investigación y Desarrollo3https://www.ebi.ac.uk/biostudies/studies/S-EPMC12814593biostudies-literatureUnknown59(1)<h4>Background</h4>Rheumatoid Arthritis (RA) is an autoimmune disease in which HLA-DRB1 alleles encoding the "Shared Epitope" (SE), located in the β-chain of class II HLA-DR molecules, constitute the main genetic risk factor. However, there is scarce information about the role of HLA class I genes (HLA-ABC) in RA susceptibility. The present work aimed to evaluate the distribution of HLA-ABC allele groups in a cohort of Chilean RA patients and healthy subjects (HS), and to explore the influence of HLA-DRB1 SE alleles on this distribution.<h4>Results</h4>135 RA patients and 122 HS were genotyped for HLA-ABC. The most frequent allele groups were HLA-A*02 (24.0%), HLA-B*39.1 (14.2%), and HLA-C*07 (24.7%) for RA patients, and HLA-A*02 (31.5%), HLA-A*24 (12.8%) and HLA-C*07 (17.7%) for HS. RA paBiological researchDistribution of HLA-ABC allele groups in a cohort of Chilean rheumatoid arthritis patients and healthy individuals.PMC1281459312400601221611Catalan DMontano-Bruno DBozan FToro LNeira OPesce BCuellar-Gutierrez MCRivera GSchneider DSoto LArroyo CPalou EJaime MAguillon JCVarela-Villarroel CMaggi JfalseDistribution of HLA-ABC allele groups in a cohort of Chilean rheumatoid arthritis patients and healthy individuals.<h4>Background</h4>Rheumatoid Arthritis (RA) is an autoimmune disease in which HLA-DRB1 alleles encoding the "Shared Epitope" (SE), located in the β-chain of class II HLA-DR molecules, constitute the main genetic risk factor. However, there is scarce information about the role of HLA class I genes (HLA-ABC) in RA susceptibility. The present work aimed to evaluate the distribution of HLA-ABC allele groups in a cohort of Chilean RA patients and healthy subjects (HS), and to explore the influence of HLA-DRB1 SE alleles on this distribution.<h4>Results</h4>135 RA patients and 122 HS were genotyped for HLA-ABC. The most frequent allele groups were HLA-A*02 (24.0%), HLA-B*39.1 (14.2%), and HLA-C*07 (24.7%) for RA patients, and HLA-A*02 (31.5%), HLA-A*24 (12.8%) and HLA-C*07 (17.7%) for HS. RA pa2025-01-01T00:00:00Z2025 Dec2026-06-06T15:03:07.928Z2026-06-01T03:10:50.922ZS-EPMC128145934144467810.1186/s40659-025-00663-w