{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gavrielatos M"],"funding":["NIH/NIA","National Institute of Neurological Disorders and Stroke","Intramural NIH HHS","Mayo Clinic Florida Morris K. Udall Parkinson's Disease Research Center of Excellence","Ted Turner and family","NIA NIH HHS","The Albertson Parkinson's Research Foundation","Mayo Clinic Dorothy and Harry T. Mangurian Jr. Lewy body dementia program","Mayo Clinic Lewy Body Dementia Association (LBDA) Research Center of Excellence","Lewy Body Dementia Association","Michael J. Fox Foundation for Parkinson's Research","Intramural Research Program of the U.S. National Institutes of Health","Haworth Family Professorship in Neurodegenerative Diseases fund","Little Family Foundation","NIH/NINDS","American Parkinson Disease Association (APDA) Center for Advanced Research","Mayo Clinic LBD Center WithOut Walls","American Parkinson Disease Association (APDA) Mayo Clinic Information and Referral Center","NINDS NIH HHS","PPND Family Foundation","American Parkinson Disease Association","Michael J. Fox Foundation for Parkinson&apos;s Research"],"pagination":["492-501"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12814941"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["99(2)"],"pubmed_abstract":["<h4>Objective</h4>Lewy body disease (LBD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded α-synuclein in the brain. Neuroinflammation has long been implicated in LBD pathogenesis, and recent genetic studies in Parkinson's disease (a clinical manifestation of LBD) have shown consistent association with the human leukocyte antigen (HLA) gene complex. Here, we assessed whether variation in HLA alleles influences neuropathological burden in a neuropathologically-defined series of LBD cases.<h4>Methods</h4>We conducted a comprehensive analysis of HLA allelic variants in a cohort of 539 LBD cases of European descent from the Mayo Clinic brain bank. High-resolution whole-genome sequencing was used, and the HLA alleles of each sample were called using the HLA"],"journal":["Annals of neurology"],"pubmed_title":["Association between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease."],"pmcid":["PMC12814941"],"funding_grant_id":["U01 NS100620","U19 AG071754","U54 NS110435","1U19AG063911","P30 AG062677","P50 NS072187","R01 AG089380","U54-NS110435","R01 AG056366","1ZIAAG000935","P50 AG016574","ZIA NS003154","U19AG063911","NINDS P50 #NS072187","ZIA AG000935","R01 AG087165","1ZIANS003154","U19 AG063911"],"pubmed_authors":["Fiesel FC","Dickson DW","Mignot E","Jack CR","Hou X","Graff-Radford NR","Botha H","Wszolek ZK","Springer W","Koga S","Boeve BF","Gibbs JR","Graff-Radford J","Murray ME","Heckman MG","Dalgard CL","Ross OA","Blumenfeld SG","Reichard RR","Petersen RC","Traynor BJ","Ramanan VK","Ferman TJ","Gan-Or Z","Uitti RJ","Gavrielatos M","Soto-Beasley AI","Fields JA","Ono D","Kasanuki K","Lowe VJ","Savica R","Kantarci K","Ertekin-Taner N","Scholz SW"],"additional_accession":[]},"is_claimable":false,"name":"Association between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease.","description":"<h4>Objective</h4>Lewy body disease (LBD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded α-synuclein in the brain. Neuroinflammation has long been implicated in LBD pathogenesis, and recent genetic studies in Parkinson's disease (a clinical manifestation of LBD) have shown consistent association with the human leukocyte antigen (HLA) gene complex. Here, we assessed whether variation in HLA alleles influences neuropathological burden in a neuropathologically-defined series of LBD cases.<h4>Methods</h4>We conducted a comprehensive analysis of HLA allelic variants in a cohort of 539 LBD cases of European descent from the Mayo Clinic brain bank. High-resolution whole-genome sequencing was used, and the HLA alleles of each sample were called using the HLA","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-15T06:44:47.572Z","creation":"2026-06-30T03:20:20.462Z"},"accession":"S-EPMC12814941","cross_references":{"pubmed":["41200866"],"doi":["10.1002/ana.78075"]}}