biostudies-literatureUnknown13(1)Celletti EAlfasigma S.p.A<h4>Introduction</h4>The efficacy and safety of filgotinib (FIL) for the treatment of patients with rheumatoid arthritis (RA) have been evaluated in a number of randomized controlled trials. However, there is a scarcity of real-world studies evaluating the effectiveness, persistence, tolerability, and safety of FIL in everyday clinical practice. This study aimed to assess the effectiveness and retention rate of FIL in a real-world cohort of patients with RA.<h4>Methods</h4>A multicenter retrospective cohort study of patients with RA treated with FIL was conducted in 27 Italian tertiary referral rheumatology centers. The drug retention rate (DRR) was estimated by the Kaplan-Meier method, while multivariate Cox regression was used to detect potential factors affecting drug survival and persiRheumatology and therapy179-193https://www.ebi.ac.uk/biostudies/studies/S-EPMC12816451biostudies-literatureFilgotinib Effectiveness in Rheumatoid Arthritis: Observational Analysis of a Large Multicenter Cohort.PMC12816451Del Biondo PSalvarani CPriora MLucchini GParoli MDitto MCFusaro EGiuggioli DDi Penta MFoti RSabatini EBecciolini ASantilli DIanniello AAddimanda OBixio RReta MColina MBezzi ANucera VCamellino DAndracco RScolieri PMansueto NCipollone FAriani AParisi SFarina AMascella FArrigoni EMolica Colella ABLo Gullo ACelletti ERavagnani VCaccavale RMarchetta ADi Donato ESmerilli GVitetta RPlate IBernardi SDe Lucia FFiorenza ALumetti FGiampietro CMolica Colella FGirelli FVolpe AVisalli EBianchi GSerale FFerrero GSandri GDel Medico PFocherini MCAmato GRovera GBruzzese VAdorni GOmetto FBravi EDal Bosco YRaffeiner BFranchina VLarosa MfalseFilgotinib Effectiveness in Rheumatoid Arthritis: Observational Analysis of a Large Multicenter Cohort.<h4>Introduction</h4>The efficacy and safety of filgotinib (FIL) for the treatment of patients with rheumatoid arthritis (RA) have been evaluated in a number of randomized controlled trials. However, there is a scarcity of real-world studies evaluating the effectiveness, persistence, tolerability, and safety of FIL in everyday clinical practice. This study aimed to assess the effectiveness and retention rate of FIL in a real-world cohort of patients with RA.<h4>Methods</h4>A multicenter retrospective cohort study of patients with RA treated with FIL was conducted in 27 Italian tertiary referral rheumatology centers. The drug retention rate (DRR) was estimated by the Kaplan-Meier method, while multivariate Cox regression was used to detect potential factors affecting drug survival and persi2026-01-01T00:00:00Z2026 Feb2026-06-06T17:19:33.968Z2026-06-03T03:10:02.537ZS-EPMC128164514134311510.1007/s40744-025-00805-2