biostudies-literatureUnknown25Yan LIntroductionOwing to the limitation in the field size of the magnetic resonance (MR)-Linac, currently, tumors with a length of >20 cm cannot be treated. Thus, the present study aimed to develop an expanded magnetic resonance imaging-guided adaptive radiotherapy (MRIgART) workflow for long, continuous planning target volumes (PTVs).MethodsThe PTVs were divided into two sub_target volumes (PTV_sub1 and PTV_sub2). We established two isocenters and defined a field overlap region. By adjusting the MR scan range, devising the online and offline adaptive procedures, synchronizing the online adaptive processes, and constructing a pretreatment dose evaluation, a new MRIgART workflow for long PTVs was established. The new workflow was validated using an in-house-made MR phantom. Additionally, the ArTechnology in cancer research & treatment15330338251408324https://www.ebi.ac.uk/biostudies/studies/S-EPMC12816554biostudies-literatureDevelopment and Validation of a Magnetic Resonance Imaging-Guided Adaptive Radiotherapy Workflow for Long, Continuous Planning Target Volumes.PMC12816554Yan LWang NLi XFu QZhang KNie WDai JMen KQin SChen DfalseDevelopment and Validation of a Magnetic Resonance Imaging-Guided Adaptive Radiotherapy Workflow for Long, Continuous Planning Target Volumes.IntroductionOwing to the limitation in the field size of the magnetic resonance (MR)-Linac, currently, tumors with a length of >20 cm cannot be treated. Thus, the present study aimed to develop an expanded magnetic resonance imaging-guided adaptive radiotherapy (MRIgART) workflow for long, continuous planning target volumes (PTVs).MethodsThe PTVs were divided into two sub_target volumes (PTV_sub1 and PTV_sub2). We established two isocenters and defined a field overlap region. By adjusting the MR scan range, devising the online and offline adaptive procedures, synchronizing the online adaptive processes, and constructing a pretreatment dose evaluation, a new MRIgART workflow for long PTVs was established. The new workflow was validated using an in-house-made MR phantom. Additionally, the Ar2026-01-01T00:00:00Z2026 Jan-Dec2026-06-12T05:09:00.805Z2026-06-12T03:08:07.146ZS-EPMC128165544155376710.1177/15330338251408324