{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Townsley JC"],"pubmed_abstract":["Herein we report the first use of accessible boron-containing compounds as highly effective directing groups for C-H activation and hydrogen isotope exchange. Selective <i>ortho</i>-activation and functionalisation at aromatic C-sp<sup>2</sup> centres have been achieved across an array of aryl boronic ester species using an iridium-based, NHC/phosphine catalyst system at low loadings. The process is robust, with a wide scope of over 30 substrates, and delivers excellent levels of deuterium incorporation in a selective manner. Further utilisation of the resulting boron-containing isotopologues in cross-coupling chemistry has allowed the late-stage preparation of previously less accessible site-selectively labelled structures. This strategy has been exemplified <i>via</i> the preparation of "],"journal":["Chemical science"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12817062"],"repository":["biostudies-literature"],"pubmed_title":["Widely-used boronic esters as synthetically-versatile directing groups for C-H activation and hydrogen isotope exchange."],"pmcid":["PMC12817062"],"pubmed_authors":["Paterson LC","Smith C","Townsley JC","Liwicki GM","Lindsay DM","Measom ND","Kerr WJ"],"additional_accession":[]},"is_claimable":false,"name":"Widely-used boronic esters as synthetically-versatile directing groups for C-H activation and hydrogen isotope exchange.","description":"Herein we report the first use of accessible boron-containing compounds as highly effective directing groups for C-H activation and hydrogen isotope exchange. Selective <i>ortho</i>-activation and functionalisation at aromatic C-sp<sup>2</sup> centres have been achieved across an array of aryl boronic ester species using an iridium-based, NHC/phosphine catalyst system at low loadings. The process is robust, with a wide scope of over 30 substrates, and delivers excellent levels of deuterium incorporation in a selective manner. Further utilisation of the resulting boron-containing isotopologues in cross-coupling chemistry has allowed the late-stage preparation of previously less accessible site-selectively labelled structures. This strategy has been exemplified <i>via</i> the preparation of ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T19:47:41.925Z","creation":"2026-06-04T03:11:31.375Z"},"accession":"S-EPMC12817062","cross_references":{"pubmed":["41567959"],"doi":["10.1039/d5sc09113f"]}}