{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li JM"],"funding":["National Heart, Lung and Blood Institute","Boston University School of Medicine and National Institute on Aging","NCATS NIH HHS","NIA NIH HHS","U.S. National Institutes of Health - National Institute of Aging","NHLBI NIH HHS","National Heart, Lung, and Blood Institute - National Institute of Neurological Disorders and Stroke","NINDS NIH HHS","National Institute for Neurologic Disorders and Stroke"],"pagination":["e71065"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12819166"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["<h4>Introduction</h4>Dementia prevalence is associated with modifiable factors. We quantified the contribution of dementia risk factors in midlife (45-64 years) and late life (≥ 65 years) in the United States.<h4>Methods</h4>Data from six community-based cohorts in the Dementia Risk Prediction Project (DRPP) were used. We estimated risk factor prevalence using nationally representative data. Cohort-specific Cox regression models were used to estimate the association between modifiable risk factors and incident dementia in midlife and late life. Hazard ratios were pooled using meta-analysis then used to calculate population attributable fractions (PAFs) and potential impact fractions.<h4>Results</h4>Midlife and late-life risk factors contributed to 22.7% and 16.5% of total dementia cases, r"],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Midlife and late-life population attributable fractions of risk factors for dementia in the United States: The Dementia Risk Prediction Project."],"pmcid":["PMC12819166"],"funding_grant_id":["75N92022D00003","75N92022D00004","R01AG023629","75N92022D00001","75N92022D00002","1R61NS120245-01/R33NS120245","UL1-TR-000040","N01-HC-25195","R01AG059421","UF1/UH1NS125513","75N92022D00005","R01AG058969","P30AG072947","RF1AG066524","1RF1AG068410-01","UL1-TR-001420","U01HL096812","75N92021D00006","P30 AG066546","HHSN268200800007C","R01AG079108-01","R01AG030153","R01AG054069","N01-HC-95169","HHSN268201800001C","U01AG052409","N01-HC-95165","N01-HC-95166","N01-HC-95167","1R01NS102715-01","N01-HC-95168","N01HC85079","HHSN268201500001I","U01AG058589","R01NS017950","UL1-TR-001079","N01-HC-95161","N01-HC-95162","N01-HC-95163","N01-HC-95164","R01AG054076","R01AG070953","R01HL172803","N01-HC-95160","U01HL080295","N01HC85081","R01AG20098","N01-HC-95159","N01HC85082","75N92020D00007","N01HC85080","HHSN268201200036C","N01HC85086","N01HC85083","75N92019D00031","75N92020D00001","75N92020D00002","75N92020D00005","75N92020D00006","75N92020D00003","U01HL130114","75N92020D00004","R01AG049607","N01HC55222","RF1AG063507","HHSN268201500003I"],"pubmed_authors":["Judd SE","Stephen JJ","Lopez OL","Gudnason V","Peterson EA","Gross AL","Helmer C","Levine DA","Briceno EM","Satizabal CL","Himali J","Zhao L","Aiello AE","Ikram MA","Hughes TM","Lloyd-Jones DM","Mansolf M","Sedaghat S","Zmora R","Li D","Fohner A","Debette S","Seshadri S","Gauen AM","Allen NB","Sorond FA","Mbangdadji D","Soumare A","Wolters FJ","Singh-Manoux A","Launer LJ","Li JM","Kohli-Lynch C","Petito LC","Giorgio K","Scholtens D"],"additional_accession":[]},"is_claimable":false,"name":"Midlife and late-life population attributable fractions of risk factors for dementia in the United States: The Dementia Risk Prediction Project.","description":"<h4>Introduction</h4>Dementia prevalence is associated with modifiable factors. We quantified the contribution of dementia risk factors in midlife (45-64 years) and late life (≥ 65 years) in the United States.<h4>Methods</h4>Data from six community-based cohorts in the Dementia Risk Prediction Project (DRPP) were used. We estimated risk factor prevalence using nationally representative data. Cohort-specific Cox regression models were used to estimate the association between modifiable risk factors and incident dementia in midlife and late life. Hazard ratios were pooled using meta-analysis then used to calculate population attributable fractions (PAFs) and potential impact fractions.<h4>Results</h4>Midlife and late-life risk factors contributed to 22.7% and 16.5% of total dementia cases, r","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T19:22:09.097Z","creation":"2026-06-04T03:12:48.804Z"},"accession":"S-EPMC12819166","cross_references":{"pubmed":["41559019"],"doi":["10.1002/alz.71065"]}}