{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Lin S"],"pubmed_abstract":["<h4>Background</h4><i>Polygonatum cyrtonema</i> Hua is a traditional medicinal plant widely used for its anti-fatigue properties, with its polysaccharides (PCPs) believed to play a key role in these effects. Steaming, a necessary step before consumption, can alter the structure of PCPs. However, the impact of steaming-induced structural changes on their anti-fatigue activity remains unexplored. This study aims to investigate how different steaming durations affect the distribution, anti-fatigue activity, and modulation of gut microbiota by PCPs.<h4>Methods</h4><i>P. cyrtonema</i> rhizomes were steamed for 0, 4, 8, and 12 h, and the polysaccharides were extracted. <i>In vivo</i> distribution was evaluated by conjugating PCPs with fluorescein isothiocyanate (FITC) for optical imaging. Anti-f"],"journal":["Frontiers in pharmacology"],"pagination":["1721319"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12819684"],"repository":["biostudies-literature"],"pubmed_title":["Steaming duration-dependent effects on the &lt;i&gt;in vivo&lt;/i&gt; distribution, anti-fatigue activity, and gut microbiota modulation of &lt;i&gt;Polygonatum cyrtonema&lt;/i&gt; Hua polysaccharides."],"pmcid":["PMC12819684"],"pubmed_authors":["Lin S","Huang J","Wang Y","Wu W","Cai X"],"additional_accession":[]},"is_claimable":false,"name":"Steaming duration-dependent effects on the &lt;i&gt;in vivo&lt;/i&gt; distribution, anti-fatigue activity, and gut microbiota modulation of &lt;i&gt;Polygonatum cyrtonema&lt;/i&gt; Hua polysaccharides.","description":"<h4>Background</h4><i>Polygonatum cyrtonema</i> Hua is a traditional medicinal plant widely used for its anti-fatigue properties, with its polysaccharides (PCPs) believed to play a key role in these effects. Steaming, a necessary step before consumption, can alter the structure of PCPs. However, the impact of steaming-induced structural changes on their anti-fatigue activity remains unexplored. This study aims to investigate how different steaming durations affect the distribution, anti-fatigue activity, and modulation of gut microbiota by PCPs.<h4>Methods</h4><i>P. cyrtonema</i> rhizomes were steamed for 0, 4, 8, and 12 h, and the polysaccharides were extracted. <i>In vivo</i> distribution was evaluated by conjugating PCPs with fluorescein isothiocyanate (FITC) for optical imaging. Anti-f","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-06T21:42:57.936Z","creation":"2026-06-05T03:11:22.919Z"},"accession":"S-EPMC12819684","cross_references":{"pubmed":["41573722"],"doi":["10.3389/fphar.2025.1721319"]}}