{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu HJ"],"funding":["National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["764"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12820061"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["Catalytic enantioselective hydroarylation of alkynes is a concise protocol towards axial, helical, and planar chirality. By using an enantioselective π-acid catalysis strategy, these enantioenriched hydroarylation products could be obtained in a green pathway; however, noble-metal catalysts are unavoidable. Here we report a copper-catalyzed intramolecular atroposelective hydroarylation of 1-alkynylindoles with (hetero)arenes, providing a modular platform for the construction of C─N axially chiral carbazolyl and phenanthryl indoles in excellent yields with good to excellent ee values. Moreover, the constructed C─N axially chiral indoles could be easily diversified to various functional group-containing chiral frameworks, and further applied as a chiral ligand in asymmetric catalysis. Importantly, this reaction represents a rare non-noble metal-catalyzed enantioselective hydroarylation of alkynes by π-acid catalysis."],"journal":["Nature communications"],"pubmed_title":["Copper-catalyzed atroposelective hydroarylation of 1-alkynylindoles."],"pmcid":["PMC12820061"],"funding_grant_id":["22301250"],"pubmed_authors":["Zhang Z","Chen CM","Zhou B","Xu HJ","Ye LW"],"additional_accession":[]},"is_claimable":false,"name":"Copper-catalyzed atroposelective hydroarylation of 1-alkynylindoles.","description":"Catalytic enantioselective hydroarylation of alkynes is a concise protocol towards axial, helical, and planar chirality. By using an enantioselective π-acid catalysis strategy, these enantioenriched hydroarylation products could be obtained in a green pathway; however, noble-metal catalysts are unavoidable. Here we report a copper-catalyzed intramolecular atroposelective hydroarylation of 1-alkynylindoles with (hetero)arenes, providing a modular platform for the construction of C─N axially chiral carbazolyl and phenanthryl indoles in excellent yields with good to excellent ee values. Moreover, the constructed C─N axially chiral indoles could be easily diversified to various functional group-containing chiral frameworks, and further applied as a chiral ligand in asymmetric catalysis. Importantly, this reaction represents a rare non-noble metal-catalyzed enantioselective hydroarylation of alkynes by π-acid catalysis.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T19:46:56.577Z","creation":"2026-06-04T03:11:28.322Z"},"accession":"S-EPMC12820061","cross_references":{"pubmed":["41381559"],"doi":["10.1038/s41467-025-67440-x"]}}