{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26(1)"],"submitter":["Yao T"],"pubmed_abstract":["<h4>Background</h4>Although the impact of baseline frailty status on chronic disease risks has been well-established, evidence on the associations between changes in frailty status and the incidence of new-onset chronic diseases remains limited.<h4>Methods</h4>A retrospective study of prospectively collected data from the China Health and Retirement Longitudinal Study (CHARLS) including 7 021 adults aged 45 years or older. Frailty status was evaluated by the Rockwood frailty index and classified as robust, pre-frail, or frail. Changes in frailty status were assessed by frailty status at baseline (2011) and the second survey (2013). All chronic diseases were identified by self-reported physician diagnosis. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) "],"journal":["BMC public health"],"pagination":["243"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12821276"],"repository":["biostudies-literature"],"pubmed_title":["Associations of changes in frailty with multiple chronic diseases in middle aged and elderly adults."],"pmcid":["PMC12821276"],"pubmed_authors":["Fan H","Lu W","Song B","Zhang X","Zhang H","Yao T","Gao G","Liu C","Liu T","Wang K","Zhao X","Guang X"],"additional_accession":[]},"is_claimable":false,"name":"Associations of changes in frailty with multiple chronic diseases in middle aged and elderly adults.","description":"<h4>Background</h4>Although the impact of baseline frailty status on chronic disease risks has been well-established, evidence on the associations between changes in frailty status and the incidence of new-onset chronic diseases remains limited.<h4>Methods</h4>A retrospective study of prospectively collected data from the China Health and Retirement Longitudinal Study (CHARLS) including 7 021 adults aged 45 years or older. Frailty status was evaluated by the Rockwood frailty index and classified as robust, pre-frail, or frail. Changes in frailty status were assessed by frailty status at baseline (2011) and the second survey (2013). All chronic diseases were identified by self-reported physician diagnosis. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T19:43:24.27Z","creation":"2026-06-04T03:12:08.312Z"},"accession":"S-EPMC12821276","cross_references":{"pubmed":["41392284"],"doi":["10.1186/s12889-025-25872-6"]}}