{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yu H"],"funding":["Postgraduates &apos; innovative scientific research project of colleges and universities in Hainan Province","Postgraduates ' innovative scientific research project of colleges and universities in Hainan Province"],"pagination":["96"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12821990"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(1)"],"pubmed_abstract":["<h4>Background</h4>Cytokeratin 19 (CK19), Ki67 antigen (Ki67), and β-catenin are abnormally overexpressed in hepatocellular carcinoma (HCC), but their diagnostic and prognostic value remains unclear. This study aims to investigate the predictive role of these three markers in post-operative survival of HCC patients.<h4>Methods</h4>The expression levels of CK19, Ki67, and β-catenin in HCC tumor tissues were determined through public datasets. Kaplan-Meier survival analysis and multivariate Cox regression were performed to evaluate their prognostic value. Immunohistochemistry and Western blotting were used to detect the expression levels of CK19, Ki67, and β-catenin in hepatocellular carcinoma tissues and adjacent non-cancerous tissues. Transcriptome sequencing was performed to analyze the d"],"journal":["BMC cancer"],"pubmed_title":["Elevated expression of CK19, Ki67, and β-Catenin as prognostic biomarkers in hepatocellular carcinoma."],"pmcid":["PMC12821990"],"funding_grant_id":["Qhys2023-498"],"pubmed_authors":["Wu J","Gao L","Yu H"],"additional_accession":[]},"is_claimable":false,"name":"Elevated expression of CK19, Ki67, and β-Catenin as prognostic biomarkers in hepatocellular carcinoma.","description":"<h4>Background</h4>Cytokeratin 19 (CK19), Ki67 antigen (Ki67), and β-catenin are abnormally overexpressed in hepatocellular carcinoma (HCC), but their diagnostic and prognostic value remains unclear. This study aims to investigate the predictive role of these three markers in post-operative survival of HCC patients.<h4>Methods</h4>The expression levels of CK19, Ki67, and β-catenin in HCC tumor tissues were determined through public datasets. Kaplan-Meier survival analysis and multivariate Cox regression were performed to evaluate their prognostic value. Immunohistochemistry and Western blotting were used to detect the expression levels of CK19, Ki67, and β-catenin in hepatocellular carcinoma tissues and adjacent non-cancerous tissues. Transcriptome sequencing was performed to analyze the d","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T19:29:45.828Z","creation":"2026-06-04T03:10:51.362Z"},"accession":"S-EPMC12821990","cross_references":{"pubmed":["41388520"],"doi":["10.1186/s12885-025-15429-6"]}}