{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yin A"],"funding":["Shenzhen Science and Technology Innovation Program","President Foundation of The Third Affiliated Hospital of Southern Medical University","National Natural Science Foundation of China"],"pagination":["97"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12822124"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["<h4>Background</h4>Preeclampsia (PE) remains a leading cause of maternal and fetal mortality, necessitating reliable first-trimester biomarkers for early identification and pathogenesis elucidation. This study aimed to evaluate the predictive performance of first-trimester serum CA125 for the PE development and to examine their longitudinal associations with blood pressure trajectories during pregnancy.<h4>Methods</h4>A nested case-control study was conducted within the prospective BiCoS cohort, including 70 PE cases and 70 matched controls. Serum CA125 levels were measured at 12.26 ± 0.44 weeks of gestation and compared using independent t-tests. Logistic regression models were built to assess the predictive performance of CA125 alone, clinical factors, and their combination. Model discri"],"journal":["Journal of translational medicine"],"pubmed_title":["Increased first-trimester CA125 levels associated with the development of preeclampsia."],"pmcid":["PMC12822124"],"funding_grant_id":["JCYJ20220818103607015","JCYJ20220818103608017","YQ202410","72374227"],"pubmed_authors":["Zeng C","Liu K","Wu L","Guan X","Zhang H","Yin A","Niu J","Chen Y","Wu X","Huang P"],"additional_accession":[]},"is_claimable":false,"name":"Increased first-trimester CA125 levels associated with the development of preeclampsia.","description":"<h4>Background</h4>Preeclampsia (PE) remains a leading cause of maternal and fetal mortality, necessitating reliable first-trimester biomarkers for early identification and pathogenesis elucidation. This study aimed to evaluate the predictive performance of first-trimester serum CA125 for the PE development and to examine their longitudinal associations with blood pressure trajectories during pregnancy.<h4>Methods</h4>A nested case-control study was conducted within the prospective BiCoS cohort, including 70 PE cases and 70 matched controls. Serum CA125 levels were measured at 12.26 ± 0.44 weeks of gestation and compared using independent t-tests. Logistic regression models were built to assess the predictive performance of CA125 alone, clinical factors, and their combination. Model discri","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T18:11:41.092Z","creation":"2026-06-04T03:11:57.959Z"},"accession":"S-EPMC12822124","cross_references":{"pubmed":["41402871"],"doi":["10.1186/s12967-025-07565-1"]}}