biostudies-literatureYin AShenzhen Science and Technology Innovation ProgramPresident Foundation of The Third Affiliated Hospital of Southern Medical UniversityNational Natural Science Foundation of China97https://www.ebi.ac.uk/biostudies/studies/S-EPMC12822124biostudies-literatureUnknown24(1)<h4>Background</h4>Preeclampsia (PE) remains a leading cause of maternal and fetal mortality, necessitating reliable first-trimester biomarkers for early identification and pathogenesis elucidation. This study aimed to evaluate the predictive performance of first-trimester serum CA125 for the PE development and to examine their longitudinal associations with blood pressure trajectories during pregnancy.<h4>Methods</h4>A nested case-control study was conducted within the prospective BiCoS cohort, including 70 PE cases and 70 matched controls. Serum CA125 levels were measured at 12.26 ± 0.44 weeks of gestation and compared using independent t-tests. Logistic regression models were built to assess the predictive performance of CA125 alone, clinical factors, and their combination. Model discriJournal of translational medicineIncreased first-trimester CA125 levels associated with the development of preeclampsia.PMC12822124JCYJ20220818103607015JCYJ20220818103608017YQ20241072374227Zeng CLiu KWu LGuan XZhang HYin ANiu JChen YWu XHuang PfalseIncreased first-trimester CA125 levels associated with the development of preeclampsia.<h4>Background</h4>Preeclampsia (PE) remains a leading cause of maternal and fetal mortality, necessitating reliable first-trimester biomarkers for early identification and pathogenesis elucidation. This study aimed to evaluate the predictive performance of first-trimester serum CA125 for the PE development and to examine their longitudinal associations with blood pressure trajectories during pregnancy.<h4>Methods</h4>A nested case-control study was conducted within the prospective BiCoS cohort, including 70 PE cases and 70 matched controls. Serum CA125 levels were measured at 12.26 ± 0.44 weeks of gestation and compared using independent t-tests. Logistic regression models were built to assess the predictive performance of CA125 alone, clinical factors, and their combination. Model discri2025-01-01T00:00:00Z2025 Dec2026-06-06T18:11:41.092Z2026-06-04T03:11:57.959ZS-EPMC128221244140287110.1186/s12967-025-07565-1