biostudies-literatureZhai Lthe National Natural Science Foundation of China19https://www.ebi.ac.uk/biostudies/studies/S-EPMC12822331biostudies-literatureUnknown19(1)<h4>Background</h4>Intratumoral angiogenesis is crucial for the proliferation and metastasis of ovarian cancer. This study aims to comprehensively analyze the impact of angiogenesis-related genes on clinical outcomes, the immune landscape, and immunotherapy response in ovarian cancer.<h4>Results</h4>Through integrated analysis of transcriptomic data from The Cancer Genome Atlas and Gene Expression Omnibus databases, we identified two novel angiogenesis subtypes that exhibited significant differences in clinicopathological features, prognostic outcomes, and tumor microenvironment characteristics. An angiogenesis-based risk score was developed, which effectively stratified patients into distinct risk groups. These groups demonstrated divergent clinical prognosis, immune cell infiltration patJournal of ovarian researchIntegrative analysis and experiments to explore GAS1 as a prognostic target for ovarian cancer based on angiogenesis-related genes.PMC1282233132471290Huang DZhang ZZhang XZhai LZheng RZhu XLiu RHe QLin LFei JZhou JfalseIntegrative analysis and experiments to explore GAS1 as a prognostic target for ovarian cancer based on angiogenesis-related genes.<h4>Background</h4>Intratumoral angiogenesis is crucial for the proliferation and metastasis of ovarian cancer. This study aims to comprehensively analyze the impact of angiogenesis-related genes on clinical outcomes, the immune landscape, and immunotherapy response in ovarian cancer.<h4>Results</h4>Through integrated analysis of transcriptomic data from The Cancer Genome Atlas and Gene Expression Omnibus databases, we identified two novel angiogenesis subtypes that exhibited significant differences in clinicopathological features, prognostic outcomes, and tumor microenvironment characteristics. An angiogenesis-based risk score was developed, which effectively stratified patients into distinct risk groups. These groups demonstrated divergent clinical prognosis, immune cell infiltration pat2025-01-01T00:00:00Z2025 Dec2026-06-06T19:20:37.146Z2026-06-04T03:12:43.871ZS-EPMC128223314140833410.1186/s13048-025-01883-0