{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Zhao W"],"funding":["Intramural NIH HHS","World Health Organization"],"pubmed_abstract":["Understanding tumor cell dynamics can improve prognosis and treatment but remains limited for lung adenocarcinoma in people who have never smoked (NS-LUAD). With RNA-seq data from 684 NS-LUAD and validation in an independent dataset, we identified three subtypes with distinct phenotypic traits and cell compositions. Additional genomic and histological data further characterized the subtypes. 'Steady', marked by low proliferation, high alveolar cell fraction, moderate-to-well differentiation, and fewer driver genes' alterations, is linked to prolonged survival and low immune evasion. 'Proliferative' shows high proliferation markers, TP53 mutations, and gene fusions. 'Chaotic', with high epithelial-to-mesenchymal transition markers, has the worst prognosis even within stage I tumors. Lacking"],"journal":["Cancer discovery"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12822368"],"repository":["biostudies-literature"],"pubmed_title":["A prognostic signature for lung adenocarcinoma in patients who have never smoked."],"pmcid":["PMC12822368"],"funding_grant_id":["001","ZIA CP005803","Z99 CA999999"],"pubmed_authors":["Kontic M","Wang D","Christiani DC","Holcatova I","Hoang PH","McElderry JP","Martinez Santamaria J","Rothman N","Chen CY","Edell ES","Wong MP","Mutreja K","Yendamuri SS","Homer R","Hua X","Chanock SJ","Brennan P","Sharma S","Yang L","Zhong X","Swiatkowska B","Khandekar A","Hofman P","Leung KC","Yang SR","Consonni D","Yang Y","Landi MT","Jones K","Lan Q","Pesatori AC","Zaridze D","Sang J","Schabath MB","Mas L","Hutchinson A","Rosenbaum J","Mukeria A","Manczuk M","Ognjanovic S","Joubert P","Zhao W","Colon-Matos FJ","Mates D","Miraftab M","Baine MK","Chang IS","Sholl LM","Savic M","Gaborieau V","Hsiung CA","Travis WD","Gould Rothberg BE","Alexandrov LB","Arrieta O","Lawrence S","Lee OW","Zhang T","Hartman C","Anyaso-Samuel S","Leduc C","Milosavljevic S","Lissowska J","Shangina O","Shi J","Saha M","Hicks B","Bosse Y","Liu G"],"additional_accession":[]},"is_claimable":false,"name":"A prognostic signature for lung adenocarcinoma in patients who have never smoked.","description":"Understanding tumor cell dynamics can improve prognosis and treatment but remains limited for lung adenocarcinoma in people who have never smoked (NS-LUAD). With RNA-seq data from 684 NS-LUAD and validation in an independent dataset, we identified three subtypes with distinct phenotypic traits and cell compositions. Additional genomic and histological data further characterized the subtypes. 'Steady', marked by low proliferation, high alveolar cell fraction, moderate-to-well differentiation, and fewer driver genes' alterations, is linked to prolonged survival and low immune evasion. 'Proliferative' shows high proliferation markers, TP53 mutations, and gene fusions. 'Chaotic', with high epithelial-to-mesenchymal transition markers, has the worst prognosis even within stage I tumors. Lacking","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-06T19:20:16.731Z","creation":"2026-06-04T03:12:35.53Z"},"accession":"S-EPMC12822368","cross_references":{"pubmed":["41165571"],"doi":["10.1158/2159-8290.cd-25-0581","10.1158/2159-8290.CD-25-0581"]}}