biostudies-literatureUnknown21(1)Gallardo-Alburqueque LA<h4>Objective</h4>To externally validate and compare the prognostic performance of four diabetic foot ulcer classifications-Meggitt-Wagner, University of Texas, SINBAD, and Saint Elian- for predicting major amputation in patients with diabetes treated at a public hospital in Peru.<h4>Materials and methods</h4>We conducted a retrospective cohort study at María Auxiliadora Hospital, one of the few referral centers in Lima with a specialized Diabetic Foot Unit. The study period was January 2015 to December 2019. Eligible patients had a lower-limb ulcer, complete clinical data recorded within 48 hours of the index healthcare encounter (hospital admission or outpatient evaluation), and at least six months of follow-up. Patients with venous ulcers or pressure ulcers related to immobilization werPloS onee0327601https://www.ebi.ac.uk/biostudies/studies/S-EPMC12822936biostudies-literatureExternal validation of the Meggitt-Wagner, Texas University, SINBAD, and Saint Elian classifications for predicting major amputation in patients with diabetes at a public hospital in Peru.PMC12822936Quispe-Landeo YUribe-Cavero LJGallardo-Alburqueque LAYovera-Aldana MChaname-Marin AfalseExternal validation of the Meggitt-Wagner, Texas University, SINBAD, and Saint Elian classifications for predicting major amputation in patients with diabetes at a public hospital in Peru.<h4>Objective</h4>To externally validate and compare the prognostic performance of four diabetic foot ulcer classifications-Meggitt-Wagner, University of Texas, SINBAD, and Saint Elian- for predicting major amputation in patients with diabetes treated at a public hospital in Peru.<h4>Materials and methods</h4>We conducted a retrospective cohort study at María Auxiliadora Hospital, one of the few referral centers in Lima with a specialized Diabetic Foot Unit. The study period was January 2015 to December 2019. Eligible patients had a lower-limb ulcer, complete clinical data recorded within 48 hours of the index healthcare encounter (hospital admission or outpatient evaluation), and at least six months of follow-up. Patients with venous ulcers or pressure ulcers related to immobilization wer2026-01-01T00:00:00Z20262026-06-06T21:34:49.269Z2026-06-05T03:11:06.204ZS-EPMC128229364156403110.1371/journal.pone.0327601