{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Wu M"],"pubmed_abstract":["<h4>Background</h4>Colorectal cancer (CRC) remains a leading cause of cancer-related morbidity and mortality worldwide. Cardamonin (CDN), a bioactive flavonoid derived from the seeds of <i>Alpinia katsumadai</i> Hayata, has demonstrated broad-spectrum anticancer potential. However, its specific mechanisms and therapeutic targets in CRC remain poorly elucidated.<h4>Methods</h4>Network pharmacology and molecular docking were employed to identify signaling pathways and targets associated with the anti-CRC activity of CDN. Cell viability, proliferation, migration, and invasion were evaluated using CCK-8, EdU, wound healing, and Transwell assays, respectively. Apoptosis and cell cycle were analyzed by flow cytometry. Proteomic profiling was applied to explore the underlying mechanisms, and the "],"journal":["Frontiers in pharmacology"],"pagination":["1739201"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12823903"],"repository":["biostudies-literature"],"pubmed_title":["Cardamonin induces apoptosis of colorectal cancer cells via targeted inhibition of the JAK/STAT3/epithelial-mesenchymal transition (EMT) signaling axis."],"pmcid":["PMC12823903"],"pubmed_authors":["Wu M","Liu Z","Du Z","Chen C","Ren D","Liu W"],"additional_accession":[]},"is_claimable":false,"name":"Cardamonin induces apoptosis of colorectal cancer cells via targeted inhibition of the JAK/STAT3/epithelial-mesenchymal transition (EMT) signaling axis.","description":"<h4>Background</h4>Colorectal cancer (CRC) remains a leading cause of cancer-related morbidity and mortality worldwide. Cardamonin (CDN), a bioactive flavonoid derived from the seeds of <i>Alpinia katsumadai</i> Hayata, has demonstrated broad-spectrum anticancer potential. However, its specific mechanisms and therapeutic targets in CRC remain poorly elucidated.<h4>Methods</h4>Network pharmacology and molecular docking were employed to identify signaling pathways and targets associated with the anti-CRC activity of CDN. Cell viability, proliferation, migration, and invasion were evaluated using CCK-8, EdU, wound healing, and Transwell assays, respectively. Apoptosis and cell cycle were analyzed by flow cytometry. Proteomic profiling was applied to explore the underlying mechanisms, and the ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-21T03:10:24.837Z","creation":"2026-06-21T03:07:35.581Z"},"accession":"S-EPMC12823903","cross_references":{"pubmed":["41585878"],"doi":["10.3389/fphar.2025.1739201"]}}