{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gonzalez JS"],"funding":["NCATS NIH HHS","Division of Diabetes, Endocrinology, and Metabolic Diseases","Centers for Disease Control and Prevention","NIDDK NIH HHS","NIA NIH HHS","National Heart, Lung, and Blood Institute","NHLBI NIH HHS","American Diabetes Association","NIGMS NIH HHS","CDC HHS"],"pagination":["335-343"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12824802"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["49(2)"],"pubmed_abstract":["<h4>Objective</h4>To address previous inconsistencies in reports of differential adherence to diabetes medications, we examined medication adherence and evaluated treatment group differences in a substudy of participants in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).<h4>Research design and methods</h4>GRADE participants (type 2 diabetes duration <10 years, HbA1c 6.8%-8.5%, on metformin alone) were randomly assigned to add insulin glargine, glimepiride, liraglutide, or sitagliptin. Adherence was measured semiannually for 3 years using a validated three-item scale (0-100, lowest to highest adherence) in a substudy (N = 1,739). Analyses included evaluation of adherence over time and testing treatment group differences in adherence and in the assoc"],"journal":["Diabetes care"],"pubmed_title":["Medication Adherence in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE)."],"pmcid":["PMC12824802"],"funding_grant_id":["R01DK104845","UL1 TR002378","UL1 TR002537","P30 DK111022","UL1 TR002535","UL1 TR000439","UL1 TR001449","UL1 TR001108","UL1 TR001409","U01DK098246","P30 DK020572","R01 DK104845","UL1 TR002243","P30 DK092926","UL1 TR002489","UL1 TR002345","UL1 TR002548","P30 DK017047","U54 GM104940","UL1 TR000445","P30DK111022","UL1 TR002529","P01 AG003949","U34DK088043","U34 DK088043","P30 DK072476","U01 DK098246","P30 DK079626","P30 DK020541"],"pubmed_authors":["Pucchetti B","Schield E","Petrovitch H","Utzschneider KM","Alfano L","Ressing A","Rhothisen S","Kuechenmeister L","Ngo L","DeManbey A","Bahtiyar G","Burgess E","Schnurr-Breen L","Magee M","Cherrington AL","Mech 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KJ"],"additional_accession":[]},"is_claimable":false,"name":"Medication Adherence in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).","description":"<h4>Objective</h4>To address previous inconsistencies in reports of differential adherence to diabetes medications, we examined medication adherence and evaluated treatment group differences in a substudy of participants in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).<h4>Research design and methods</h4>GRADE participants (type 2 diabetes duration <10 years, HbA1c 6.8%-8.5%, on metformin alone) were randomly assigned to add insulin glargine, glimepiride, liraglutide, or sitagliptin. Adherence was measured semiannually for 3 years using a validated three-item scale (0-100, lowest to highest adherence) in a substudy (N = 1,739). Analyses included evaluation of adherence over time and testing treatment group differences in adherence and in the assoc","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-06-05T03:25:42.464Z","creation":"2026-06-05T03:12:11.586Z"},"accession":"S-EPMC12824802","cross_references":{"pubmed":["41557987"],"doi":["10.2337/dc25-2008"]}}