{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nath A"],"funding":["Mats Paulssons Stiftelse","Sten K Johnsons stiftelse","Vetenskapsr?det"],"pagination":["1252-1261"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12824985"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["98(2)"],"pubmed_abstract":["We present an integrated acoustofluidic plasmapheresis system designed for ultralow blood volume applications, such as neonatal care, enabling in-line sampling and plasma separation from whole blood. The system combines a two-stage acoustophoresis chip with microperistaltic pumps and PDMS-based flow pulsation dampeners to ensure continuous, stable operation. The input whole blood is acoustically separated into a cell-free plasma fraction and a returnable cell fraction, enabling closed-loop operation for neonates who have a circulating blood volume as low as 50 mL. The system achieves a plasma generation rate of 27.5 μL/min with ∼100% cell removal, outperforming previous microfluidic plasma separation approaches in terms of purity, throughput, and minimal sample volume. Plasma quality was v"],"journal":["Analytical chemistry"],"pubmed_title":["Acoustofluidic Plasmapheresis System Designed for Ultralow Blood Volume Applications."],"pmcid":["PMC12824985"],"funding_grant_id":["2019-00795"],"pubmed_authors":["Nilsson L","Laurell T","Qiu W","Larsson SM","Thymann T","Gram M","Baasch T","Pankratova S","Ley D","Lenshof A","Nath A"],"additional_accession":[]},"is_claimable":false,"name":"Acoustofluidic Plasmapheresis System Designed for Ultralow Blood Volume Applications.","description":"We present an integrated acoustofluidic plasmapheresis system designed for ultralow blood volume applications, such as neonatal care, enabling in-line sampling and plasma separation from whole blood. The system combines a two-stage acoustophoresis chip with microperistaltic pumps and PDMS-based flow pulsation dampeners to ensure continuous, stable operation. The input whole blood is acoustically separated into a cell-free plasma fraction and a returnable cell fraction, enabling closed-loop operation for neonates who have a circulating blood volume as low as 50 mL. The system achieves a plasma generation rate of 27.5 μL/min with ∼100% cell removal, outperforming previous microfluidic plasma separation approaches in terms of purity, throughput, and minimal sample volume. Plasma quality was v","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T20:10:56.171Z","creation":"2026-06-04T03:14:18.987Z"},"accession":"S-EPMC12824985","cross_references":{"pubmed":["41493991"],"doi":["10.1021/acs.analchem.5c04042"]}}