{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["208(1)"],"submitter":["Babcock M"],"pubmed_abstract":["Indigoidine is a blue pigment synthesized by several bacteria, including <i>Vogesella indigofera</i>. Industrial production of indigoidine has been a research focus, but less is known about why bacteria make this pigment or how its biosynthesis is regulated. We isolated <i>V. indigofera</i> strain OSW_575 and investigated the basis for its indigoidine production using genomic and genetic approaches. Mutation of the indigoidine synthase gene <i>igiD</i> eliminated pigment production, and complementation restored it. A transposon mutagenesis screen uncovered 34 mutations across 20 genes that affect pigment production, including some involved in metabolism, translation, protein homeostasis, and regulation. Three chaperones that combat misfolded proteins, <i>dnaK</i>, <i>dnaJ</i>, and <i>grpE<"],"journal":["Journal of bacteriology"],"pagination":["e0036425"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12826045"],"repository":["biostudies-literature"],"pubmed_title":["Regulation of indigoidine production in &lt;i&gt;Vogesella indigofera&lt;/i&gt; by a novel two-component system."],"pmcid":["PMC12826045"],"pubmed_authors":["Romanelli K","Babcock M","Gonzalez S","Newell PD","Robinson G"],"additional_accession":[]},"is_claimable":false,"name":"Regulation of indigoidine production in &lt;i&gt;Vogesella indigofera&lt;/i&gt; by a novel two-component system.","description":"Indigoidine is a blue pigment synthesized by several bacteria, including <i>Vogesella indigofera</i>. Industrial production of indigoidine has been a research focus, but less is known about why bacteria make this pigment or how its biosynthesis is regulated. We isolated <i>V. indigofera</i> strain OSW_575 and investigated the basis for its indigoidine production using genomic and genetic approaches. Mutation of the indigoidine synthase gene <i>igiD</i> eliminated pigment production, and complementation restored it. A transposon mutagenesis screen uncovered 34 mutations across 20 genes that affect pigment production, including some involved in metabolism, translation, protein homeostasis, and regulation. Three chaperones that combat misfolded proteins, <i>dnaK</i>, <i>dnaJ</i>, and <i>grpE<","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T22:04:15.738Z","creation":"2026-06-05T03:12:13.248Z"},"accession":"S-EPMC12826045","cross_references":{"pubmed":["41334928"],"doi":["10.1128/jb.00364-25"]}}