{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ashton L"],"funding":["NCATS NIH HHS"],"pagination":["63-68"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12826440"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["193"],"pubmed_abstract":["Objective
To determine the efficacy of a single injection of platelet-rich plasma (PRP) into the anterior vaginal wall at the mid-urethra compared to placebo, as there is emerging evidence that PRP may help treat female stress urinary incontinence (SUI).Methods
This was a single-blind, randomized, placebo-controlled clinical trial at a single institution. Females with bothersome, demonstrable stress-predominant urinary incontinence were enrolled. Participants were randomized to either injection of 5 mL autologous PRP or saline at the anterior vaginal wall at the mid-urethra. The primary outcome was composite treatment success at 6 months, defined as a negative cough stress test and an answer of \"much better\" or \"very much better\" on the Patient's Global Impression of Improv"],"journal":["Urology"],"pubmed_title":["A Single Injection of Platelet-rich Plasma Injection for the Treatment of Stress Urinary Incontinence in Females: A Randomized Placebo-controlled Trial."],"pmcid":["PMC12826440"],"funding_grant_id":["UM1 TR004403"],"pubmed_authors":["Kruse R","Takacs EB","Vollstedt AJ","Kenne K","Wendt L","Johnson CM","Nakatsuka H","Kreder KJ","Ashton L"],"additional_accession":[]},"is_claimable":false,"name":"A Single Injection of Platelet-rich Plasma Injection for the Treatment of Stress Urinary Incontinence in Females: A Randomized Placebo-controlled Trial.","description":"Objective
To determine the efficacy of a single injection of platelet-rich plasma (PRP) into the anterior vaginal wall at the mid-urethra compared to placebo, as there is emerging evidence that PRP may help treat female stress urinary incontinence (SUI).Methods
This was a single-blind, randomized, placebo-controlled clinical trial at a single institution. Females with bothersome, demonstrable stress-predominant urinary incontinence were enrolled. Participants were randomized to either injection of 5 mL autologous PRP or saline at the anterior vaginal wall at the mid-urethra. The primary outcome was composite treatment success at 6 months, defined as a negative cough stress test and an answer of \"much better\" or \"very much better\" on the Patient's Global Impression of Improv","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-06T22:01:09.934Z","creation":"2026-06-05T03:12:06.824Z"},"accession":"S-EPMC12826440","cross_references":{"pubmed":["38942391"],"doi":["10.1016/j.urology.2024.06.047"]}}