biostudies-literatureAshton LNCATS NIH HHS63-68https://www.ebi.ac.uk/biostudies/studies/S-EPMC12826440biostudies-literatureUnknown193<h4>Objective</h4>To determine the efficacy of a single injection of platelet-rich plasma (PRP) into the anterior vaginal wall at the mid-urethra compared to placebo, as there is emerging evidence that PRP may help treat female stress urinary incontinence (SUI).<h4>Methods</h4>This was a single-blind, randomized, placebo-controlled clinical trial at a single institution. Females with bothersome, demonstrable stress-predominant urinary incontinence were enrolled. Participants were randomized to either injection of 5 mL autologous PRP or saline at the anterior vaginal wall at the mid-urethra. The primary outcome was composite treatment success at 6 months, defined as a negative cough stress test and an answer of "much better" or "very much better" on the Patient's Global Impression of ImprovUrologyA Single Injection of Platelet-rich Plasma Injection for the Treatment of Stress Urinary Incontinence in Females: A Randomized Placebo-controlled Trial.PMC12826440UM1 TR004403Kruse RTakacs EBVollstedt AJKenne KWendt LJohnson CMNakatsuka HKreder KJAshton LfalseA Single Injection of Platelet-rich Plasma Injection for the Treatment of Stress Urinary Incontinence in Females: A Randomized Placebo-controlled Trial.<h4>Objective</h4>To determine the efficacy of a single injection of platelet-rich plasma (PRP) into the anterior vaginal wall at the mid-urethra compared to placebo, as there is emerging evidence that PRP may help treat female stress urinary incontinence (SUI).<h4>Methods</h4>This was a single-blind, randomized, placebo-controlled clinical trial at a single institution. Females with bothersome, demonstrable stress-predominant urinary incontinence were enrolled. Participants were randomized to either injection of 5 mL autologous PRP or saline at the anterior vaginal wall at the mid-urethra. The primary outcome was composite treatment success at 6 months, defined as a negative cough stress test and an answer of "much better" or "very much better" on the Patient's Global Impression of Improv2024-01-01T00:00:00Z2024 Nov2026-06-06T22:01:09.934Z2026-06-05T03:12:06.824ZS-EPMC128264403894239110.1016/j.urology.2024.06.047