{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(1)"],"submitter":["Beuker C"],"pubmed_abstract":["<h4>Objectives</h4>Despite being a major cause of ischemic stroke in young adults, the biological underpinnings of cervical artery dissection (CeAD) remain poorly defined. Recent data implicate immune activation as a potential contributor. We aimed to determine whether patients with CeAD display a distinct peripheral immune signature, which may provide insights into pathogenic inflammatory processes.<h4>Methods</h4>Peripheral blood mononuclear cells (PBMCs) from patients with spontaneous CeAD (n = 7 without and n = 11 with ischemic stroke) and ten age-matched healthy controls were analyzed via multi-color flow cytometry. Immune cell composition and activation markers were assessed, and sparse partial least squares discriminant analysis (sPLS-DA) was employed to identify CeAD-associated imm"],"journal":["PloS one"],"pagination":["e0340592"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12826460"],"repository":["biostudies-literature"],"pubmed_title":["Spontaneous cervical artery dissection is associated with a distinct peripheral immune cell signature."],"pmcid":["PMC12826460"],"pubmed_authors":["Minnerup J","Kleffner I","Gross CC","Klotz L","Beuker C","Strunk D","Schmidt-Pogoda A","Thomas C","Schulte-Mecklenbeck A","Wirth T"],"additional_accession":[]},"is_claimable":false,"name":"Spontaneous cervical artery dissection is associated with a distinct peripheral immune cell signature.","description":"<h4>Objectives</h4>Despite being a major cause of ischemic stroke in young adults, the biological underpinnings of cervical artery dissection (CeAD) remain poorly defined. Recent data implicate immune activation as a potential contributor. We aimed to determine whether patients with CeAD display a distinct peripheral immune signature, which may provide insights into pathogenic inflammatory processes.<h4>Methods</h4>Peripheral blood mononuclear cells (PBMCs) from patients with spontaneous CeAD (n = 7 without and n = 11 with ischemic stroke) and ten age-matched healthy controls were analyzed via multi-color flow cytometry. Immune cell composition and activation markers were assessed, and sparse partial least squares discriminant analysis (sPLS-DA) was employed to identify CeAD-associated imm","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026","modification":"2026-06-05T03:21:41.229Z","creation":"2026-06-05T03:11:40.835Z"},"accession":"S-EPMC12826460","cross_references":{"pubmed":["41570020"],"doi":["10.1371/journal.pone.0340592"]}}