{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["De Tommasi O"],"pubmed_abstract":["<h4>Background</h4>Ovarian carcinosarcoma (OCS), also known as malignant mixed Müllerian tumor, is a rare and highly aggressive subtype of epithelial ovarian cancer, accounting for less than 4% of all cases. It typically presents at advanced stages and is associated with dismal outcomes, with a five-year survival rate below 30%. Despite improvements in cytoreductive surgery and systemic therapies, long-term survival in stage IV disease remains exceedingly uncommon.<h4>Case presentation</h4>We report two exceptional cases of stage IVB Müllerian carcinosarcoma occurring in BRCA wild-type postmenopausal women who achieved prolonged complete remission exceeding five years after multimodal management. The first patient, aged 61, presented with bilateral adnexal masses and a solitary pulmonary m"],"journal":["Frontiers in oncology"],"pagination":["1728398"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12827093"],"repository":["biostudies-literature"],"pubmed_title":["Stage IVB ovarian carcinosarcoma in BRCA wild-type patients: two case reports of unexpected long-term remission."],"pmcid":["PMC12827093"],"pubmed_authors":["Massa D","Noventa M","Saccardi C","Bigardi S","Nardin M","Tozzi R","Spagnol G","Guerriero A","De Tommasi O","Tasca G"],"additional_accession":[]},"is_claimable":false,"name":"Stage IVB ovarian carcinosarcoma in BRCA wild-type patients: two case reports of unexpected long-term remission.","description":"<h4>Background</h4>Ovarian carcinosarcoma (OCS), also known as malignant mixed Müllerian tumor, is a rare and highly aggressive subtype of epithelial ovarian cancer, accounting for less than 4% of all cases. It typically presents at advanced stages and is associated with dismal outcomes, with a five-year survival rate below 30%. Despite improvements in cytoreductive surgery and systemic therapies, long-term survival in stage IV disease remains exceedingly uncommon.<h4>Case presentation</h4>We report two exceptional cases of stage IVB Müllerian carcinosarcoma occurring in BRCA wild-type postmenopausal women who achieved prolonged complete remission exceeding five years after multimodal management. The first patient, aged 61, presented with bilateral adnexal masses and a solitary pulmonary m","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-06T22:28:26.97Z","creation":"2026-06-06T03:10:31.629Z"},"accession":"S-EPMC12827093","cross_references":{"pubmed":["41584593"],"doi":["10.3389/fonc.2025.1728398"]}}