biostudies-literatureUnknown15De Tommasi O<h4>Background</h4>Ovarian carcinosarcoma (OCS), also known as malignant mixed Müllerian tumor, is a rare and highly aggressive subtype of epithelial ovarian cancer, accounting for less than 4% of all cases. It typically presents at advanced stages and is associated with dismal outcomes, with a five-year survival rate below 30%. Despite improvements in cytoreductive surgery and systemic therapies, long-term survival in stage IV disease remains exceedingly uncommon.<h4>Case presentation</h4>We report two exceptional cases of stage IVB Müllerian carcinosarcoma occurring in BRCA wild-type postmenopausal women who achieved prolonged complete remission exceeding five years after multimodal management. The first patient, aged 61, presented with bilateral adnexal masses and a solitary pulmonary mFrontiers in oncology1728398https://www.ebi.ac.uk/biostudies/studies/S-EPMC12827093biostudies-literatureStage IVB ovarian carcinosarcoma in BRCA wild-type patients: two case reports of unexpected long-term remission.PMC12827093Massa DNoventa MSaccardi CBigardi SNardin MTozzi RSpagnol GGuerriero ADe Tommasi OTasca GfalseStage IVB ovarian carcinosarcoma in BRCA wild-type patients: two case reports of unexpected long-term remission.<h4>Background</h4>Ovarian carcinosarcoma (OCS), also known as malignant mixed Müllerian tumor, is a rare and highly aggressive subtype of epithelial ovarian cancer, accounting for less than 4% of all cases. It typically presents at advanced stages and is associated with dismal outcomes, with a five-year survival rate below 30%. Despite improvements in cytoreductive surgery and systemic therapies, long-term survival in stage IV disease remains exceedingly uncommon.<h4>Case presentation</h4>We report two exceptional cases of stage IVB Müllerian carcinosarcoma occurring in BRCA wild-type postmenopausal women who achieved prolonged complete remission exceeding five years after multimodal management. The first patient, aged 61, presented with bilateral adnexal masses and a solitary pulmonary m2025-01-01T00:00:00Z20252026-06-06T22:28:26.97Z2026-06-06T03:10:31.629ZS-EPMC128270934158459310.3389/fonc.2025.1728398