{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Luo L"],"funding":["Beijing Municipal Natural Science Foundation","Capital Medical University Innovation Project","National Natural Science Foundation of China"],"pagination":["2862"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12828024"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Myeloperoxidase (MPO) is associated with conduction inhomogeneity. We hypothesized that MPO in selectively drained pericardial fluid (PCF), a direct window into the cardiac microenvironment, may improve postoperative atrial fibrillation (POAF) risk prediction beyond existing risk scores. A total of 469 consecutive patients undergoing coronary artery bypass grafting (CABG) were enrolled in this study (n = 201 in derivation cohort and n = 268 in validation cohort). The primary outcome was new-onset POAF within the first 7 days postoperatively. MPO concentrations were measured in selectively drained PCF and peripheral blood at baseline, 0 and 6 h postoperatively. We further compared MPO levels between pure pericardial fluid and mixed drainage fluid (via Y-connector). A new prediction model, the pcMPO-AF rule, was developed using multivariable logistic regression and validated internally using bootstrapping and externally in an independent cohort. Approximately 98.0% of patients underwent off-pump CABG. POAF occurred in 31.8% and 35.1% of the derivation and validation cohorts, respectively. Pericardial MPO at 6 h postoperatively emerged as the strongest independent predictor of POAF. MPO concentrations in selectively drained PCF were 25-fold higher than mixed drainage samples and 1,648-fold higher than serum levels (both P < 0.001). The pcMPO-AF rule demonstrated good discrimination, with AUCs of 0.908 in derivation and 0.865 in validation cohorts, outperforming POAF, CHA₂DS₂-VASc, and HATCH scores. MPO in selectively drained PCF is a potent biomarker of POAF. The pcMPO-AF rule integrated PCF biomarkers with clinical factors, providing superior predictive performance by capturing both the vulnerable atrial substrate and acute inflammatory trigger."],"journal":["Scientific reports"],"pubmed_title":["The pcMPO-AF rule for predicting postoperative atrial fibrillation after coronary artery bypass grafting."],"pmcid":["PMC12828024"],"funding_grant_id":["82200351, Y.L.","7252277, Y.L.","XSKY2024147, Y.L."],"pubmed_authors":["Yang H","Liu Y","Peng T","Luo L","Wang T","Zhou W","Shu Y","Gao C"],"additional_accession":[]},"is_claimable":false,"name":"The pcMPO-AF rule for predicting postoperative atrial fibrillation after coronary artery bypass grafting.","description":"Myeloperoxidase (MPO) is associated with conduction inhomogeneity. We hypothesized that MPO in selectively drained pericardial fluid (PCF), a direct window into the cardiac microenvironment, may improve postoperative atrial fibrillation (POAF) risk prediction beyond existing risk scores. A total of 469 consecutive patients undergoing coronary artery bypass grafting (CABG) were enrolled in this study (n = 201 in derivation cohort and n = 268 in validation cohort). The primary outcome was new-onset POAF within the first 7 days postoperatively. MPO concentrations were measured in selectively drained PCF and peripheral blood at baseline, 0 and 6 h postoperatively. We further compared MPO levels between pure pericardial fluid and mixed drainage fluid (via Y-connector). A new prediction model, the pcMPO-AF rule, was developed using multivariable logistic regression and validated internally using bootstrapping and externally in an independent cohort. Approximately 98.0% of patients underwent off-pump CABG. POAF occurred in 31.8% and 35.1% of the derivation and validation cohorts, respectively. Pericardial MPO at 6 h postoperatively emerged as the strongest independent predictor of POAF. MPO concentrations in selectively drained PCF were 25-fold higher than mixed drainage samples and 1,648-fold higher than serum levels (both P < 0.001). The pcMPO-AF rule demonstrated good discrimination, with AUCs of 0.908 in derivation and 0.865 in validation cohorts, outperforming POAF, CHA₂DS₂-VASc, and HATCH scores. MPO in selectively drained PCF is a potent biomarker of POAF. The pcMPO-AF rule integrated PCF biomarkers with clinical factors, providing superior predictive performance by capturing both the vulnerable atrial substrate and acute inflammatory trigger.","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T21:47:17.931Z","creation":"2026-06-05T03:11:56.852Z"},"accession":"S-EPMC12828024","cross_references":{"pubmed":["41565722"],"doi":["10.1038/s41598-025-32318-x"]}}