{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Patel C"],"funding":["NCI NIH HHS","National Institutes of Health","NIGMS NIH HHS","New Jersey Commission on Cancer Research"],"pagination":["103355"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12828330"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["111"],"pubmed_abstract":["Current chemotherapy regimens have significantly improved overall survival for children with cancer. However, these treatments are associated with detrimental side effects like chemotherapy-induced cognitive impairment (CICI), or \"chemobrain.\" Measurable deficits in cognitive function persist years after treatment. Specifically, doxorubicin (DOXO), a commonly used chemotherapeutic agent in curative regimens for children with cancer, plays a pivotal role in the development of CICI, even though it doesn't cross the blood-brain barrier (BBB). Using a juvenile rat model, we found that DOXO compromises the BBB integrity. To further address the poorly understood mechanism of DOXO-related CICI, we utilized human cerebral microvascular endothelial cells (hCMEC/D3) to study the changes induced by D"],"journal":["Neurotoxicology"],"pubmed_title":["The effects of doxorubicin on blood-brain barrier integrity in hCMEC/D3."],"pmcid":["PMC12828330"],"funding_grant_id":["R01 CA293210","T32 GM135141","COCR24PRF009"],"pubmed_authors":["Cole PD","Patel C","Glytsou C","Jang MH"],"additional_accession":[]},"is_claimable":false,"name":"The effects of doxorubicin on blood-brain barrier integrity in hCMEC/D3.","description":"Current chemotherapy regimens have significantly improved overall survival for children with cancer. However, these treatments are associated with detrimental side effects like chemotherapy-induced cognitive impairment (CICI), or \"chemobrain.\" Measurable deficits in cognitive function persist years after treatment. Specifically, doxorubicin (DOXO), a commonly used chemotherapeutic agent in curative regimens for children with cancer, plays a pivotal role in the development of CICI, even though it doesn't cross the blood-brain barrier (BBB). Using a juvenile rat model, we found that DOXO compromises the BBB integrity. To further address the poorly understood mechanism of DOXO-related CICI, we utilized human cerebral microvascular endothelial cells (hCMEC/D3) to study the changes induced by D","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T22:04:31.763Z","creation":"2026-06-05T03:12:15.413Z"},"accession":"S-EPMC12828330","cross_references":{"pubmed":["41265652"],"doi":["10.1016/j.neuro.2025.103355"]}}