{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["29(1)"],"submitter":["Fang Y"],"pubmed_abstract":["Pluripotency, the ability of cells to self-renew and differentiate into all body lineages, is vital for mammalian early development. This study presented a comprehensive comparative transcriptomic analysis of embryonic stem cells across multiple mammalian species, defining their progression through expanded/extended, naive, formative, and primed pluripotency states. Our findings revealed both conserved and species-specific mechanisms underlying pluripotency regulation. We also emphasized the limitations of existing state-specific markers and their limited cross-species applicability, while identifying <i>de novo</i> pluripotency markers. Despite variability in gene expression dynamics, gene co-expression networks showed remarkable conservation across species. Among pluripotency states, the"],"journal":["iScience"],"pagination":["114542"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12828385"],"repository":["biostudies-literature"],"pubmed_title":["Comparative transcriptomic analysis of embryonic stem cells across mammalian species."],"pmcid":["PMC12828385"],"pubmed_authors":["Li G","Biga PR","Shi M","Zhang J","Duan JE","Wilkinson GS","Tian XC","Larschan E","Randolph EC","Fang Y","IISAGE Consortium","Bronikowski AM","Meisel R","Gamble T","Singh R","Su Y","Walters JR","Webb A","Yu X","Tang Y","Riddle NC"],"additional_accession":[]},"is_claimable":false,"name":"Comparative transcriptomic analysis of embryonic stem cells across mammalian species.","description":"Pluripotency, the ability of cells to self-renew and differentiate into all body lineages, is vital for mammalian early development. This study presented a comprehensive comparative transcriptomic analysis of embryonic stem cells across multiple mammalian species, defining their progression through expanded/extended, naive, formative, and primed pluripotency states. Our findings revealed both conserved and species-specific mechanisms underlying pluripotency regulation. We also emphasized the limitations of existing state-specific markers and their limited cross-species applicability, while identifying <i>de novo</i> pluripotency markers. Despite variability in gene expression dynamics, gene co-expression networks showed remarkable conservation across species. Among pluripotency states, the","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-21T04:45:32.099Z","creation":"2026-06-21T03:07:33.551Z"},"accession":"S-EPMC12828385","cross_references":{"pubmed":["41583562"],"doi":["10.1016/j.isci.2025.114542"]}}