biostudies-literatureShrestha SNational Social Science Fund of China3477-3498https://www.ebi.ac.uk/biostudies/studies/S-EPMC12828720biostudies-literatureUnknown18(2)Fibrous scaffolds are emerging as key biomaterials in regenerative medicine, which provide structural and biochemical support for tissue repair. Despite new advancements in the field, many fibrous scaffolds still face intrinsic limitations, including suboptimal biodegradability, inadequate bioactivity, and limited control over therapeutic release, all of which hinder their broader biomedical applications. To address these challenges, we fabricated electrospun poly(glycolic-<i>co</i>-lactic acid) (PLGA) fibrous scaffolds embedded with various weight percentages (wt %) of zinc nanoparticles (Zn NPs), and then their physicochemical and biocompatibility properties were evaluated. The scaffold containing 1.0 wt % Zn NPs (PLZ2) exhibited controlled release of Zn²⁺, followed by a downwACS applied materials & interfacesZinc-Releasing Fibrous Scaffolds Modulate Fibroblast, Endothelial, and Macrophage Interactions for Vascularized Tissue Engineering.PMC128287202100861NSF 2315654Auniq RBZShrestha BKShrestha SBhattarai NParajuli NDesai SfalseZinc-Releasing Fibrous Scaffolds Modulate Fibroblast, Endothelial, and Macrophage Interactions for Vascularized Tissue Engineering.Fibrous scaffolds are emerging as key biomaterials in regenerative medicine, which provide structural and biochemical support for tissue repair. Despite new advancements in the field, many fibrous scaffolds still face intrinsic limitations, including suboptimal biodegradability, inadequate bioactivity, and limited control over therapeutic release, all of which hinder their broader biomedical applications. To address these challenges, we fabricated electrospun poly(glycolic-<i>co</i>-lactic acid) (PLGA) fibrous scaffolds embedded with various weight percentages (wt %) of zinc nanoparticles (Zn NPs), and then their physicochemical and biocompatibility properties were evaluated. The scaffold containing 1.0 wt % Zn NPs (PLZ2) exhibited controlled release of Zn²⁺, followed by a downw2026-01-01T00:00:00Z2026 Jan2026-06-06T20:06:25.552Z2026-06-04T03:14:18.912ZS-EPMC128287204149337810.1021/acsami.5c16589