{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["31"],"submitter":["Zhang X"],"pubmed_abstract":["Liver fibrosis, a cardinal feature of chronic liver injury, involves hepatic stellate cells (HSCs) activation and excessive extracellular matrix (ECM) deposition. Upon liver fibrosis, TLR4 is highly expressed on HSCs and Kupffer cells. TLR4 activation induces liver inflammation followed by exacerbated fibrosis. Inhibition of TLR4 signaling represents a validated anti-liver fibrosis therapeutic approach. In the realm of liver fibrosis treatment, traditional Chinese medicine (TCM) has demonstrated certain anti-fibrotic effects in clinical practice after long-term application. However, due to the complex composition of TCM, understanding the underlying biological mechanisms and controlling drug quality remain challenging. To address these issues, this study developed a database of potential a"],"journal":["Computational and structural biotechnology journal"],"pagination":["363-376"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12829150"],"repository":["biostudies-literature"],"pubmed_title":["Bicuculline from <i>Forsythia suspensa</i> attenuates liver fibrosis via TLR4/MD2 inhibition and suppression of MyD88/NF-κB signaling."],"pmcid":["PMC12829150"],"pubmed_authors":["Liu Z","Huang T","Zhang X","Peng S","Wu G","Xu H","Li K"],"additional_accession":[]},"is_claimable":false,"name":"Bicuculline from <i>Forsythia suspensa</i> attenuates liver fibrosis via TLR4/MD2 inhibition and suppression of MyD88/NF-κB signaling.","description":"Liver fibrosis, a cardinal feature of chronic liver injury, involves hepatic stellate cells (HSCs) activation and excessive extracellular matrix (ECM) deposition. Upon liver fibrosis, TLR4 is highly expressed on HSCs and Kupffer cells. TLR4 activation induces liver inflammation followed by exacerbated fibrosis. Inhibition of TLR4 signaling represents a validated anti-liver fibrosis therapeutic approach. In the realm of liver fibrosis treatment, traditional Chinese medicine (TCM) has demonstrated certain anti-fibrotic effects in clinical practice after long-term application. However, due to the complex composition of TCM, understanding the underlying biological mechanisms and controlling drug quality remain challenging. To address these issues, this study developed a database of potential a","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026","modification":"2026-06-06T22:28:46.612Z","creation":"2026-06-06T03:10:34.717Z"},"accession":"S-EPMC12829150","cross_references":{"pubmed":["41585934"],"doi":["10.1016/j.csbj.2025.12.026"]}}