{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ma X"],"funding":["the Health Commission of Jilin Province","the transverse project","the National Natural Science Foundation of China"],"pagination":["22"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12829294"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["Ovarian cancer (OC) remains a highly lethal gynecologic malignancy characterized by substantial molecular heterogeneity and diagnostic challenges. Although many reviews examine specific aspects of OC biology or treatment, few attempt to connect recent findings into a broader and coherent picture. This review provides an integrated and forward-looking synthesis of emerging mechanisms and therapeutic trends in OC, understanding OC progression and therapeutic resistance. Unique contributions of this review include providing a unified interpretation of emerging multi-omics evidence that reshapes the biological understanding of individual OC histotypes, delineating key metabolic dependencies such as glutamine addiction, aberrant lipid remodeling, glycolytic plasticity and purine pathway rewirin"],"journal":["Journal of ovarian research"],"pubmed_title":["Advances in ovarian cancer: biological insights, therapeutic innovations, and future perspectives."],"pmcid":["PMC12829294"],"funding_grant_id":["No.82160552","202501-202912","2024B001"],"pubmed_authors":["Yang Y","Qu L","Wu Q","Yu Q","Ma X","Lin Z","Zhou X"],"additional_accession":[]},"is_claimable":false,"name":"Advances in ovarian cancer: biological insights, therapeutic innovations, and future perspectives.","description":"Ovarian cancer (OC) remains a highly lethal gynecologic malignancy characterized by substantial molecular heterogeneity and diagnostic challenges. Although many reviews examine specific aspects of OC biology or treatment, few attempt to connect recent findings into a broader and coherent picture. This review provides an integrated and forward-looking synthesis of emerging mechanisms and therapeutic trends in OC, understanding OC progression and therapeutic resistance. Unique contributions of this review include providing a unified interpretation of emerging multi-omics evidence that reshapes the biological understanding of individual OC histotypes, delineating key metabolic dependencies such as glutamine addiction, aberrant lipid remodeling, glycolytic plasticity and purine pathway rewirin","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-13T05:06:30.439Z","creation":"2026-06-13T03:08:41.961Z"},"accession":"S-EPMC12829294","cross_references":{"pubmed":["41354809"],"doi":["10.1186/s13048-025-01921-x"]}}