biostudies-literatureMa Xthe Health Commission of Jilin Provincethe transverse projectthe National Natural Science Foundation of China22https://www.ebi.ac.uk/biostudies/studies/S-EPMC12829294biostudies-literatureUnknown19(1)Ovarian cancer (OC) remains a highly lethal gynecologic malignancy characterized by substantial molecular heterogeneity and diagnostic challenges. Although many reviews examine specific aspects of OC biology or treatment, few attempt to connect recent findings into a broader and coherent picture. This review provides an integrated and forward-looking synthesis of emerging mechanisms and therapeutic trends in OC, understanding OC progression and therapeutic resistance. Unique contributions of this review include providing a unified interpretation of emerging multi-omics evidence that reshapes the biological understanding of individual OC histotypes, delineating key metabolic dependencies such as glutamine addiction, aberrant lipid remodeling, glycolytic plasticity and purine pathway rewirinJournal of ovarian researchAdvances in ovarian cancer: biological insights, therapeutic innovations, and future perspectives.PMC12829294No.82160552202501-2029122024B001Yang YQu LWu QYu QMa XLin ZZhou XfalseAdvances in ovarian cancer: biological insights, therapeutic innovations, and future perspectives.Ovarian cancer (OC) remains a highly lethal gynecologic malignancy characterized by substantial molecular heterogeneity and diagnostic challenges. Although many reviews examine specific aspects of OC biology or treatment, few attempt to connect recent findings into a broader and coherent picture. This review provides an integrated and forward-looking synthesis of emerging mechanisms and therapeutic trends in OC, understanding OC progression and therapeutic resistance. Unique contributions of this review include providing a unified interpretation of emerging multi-omics evidence that reshapes the biological understanding of individual OC histotypes, delineating key metabolic dependencies such as glutamine addiction, aberrant lipid remodeling, glycolytic plasticity and purine pathway rewirin2025-01-01T00:00:00Z2025 Dec2026-06-13T05:06:30.439Z2026-06-13T03:08:41.961ZS-EPMC128292944135480910.1186/s13048-025-01921-x