biostudies-literatureUnknown31(14)Hennessee ISome patients with coccidioidomycosis experience prolonged respiratory and systemic symptoms. However, data on prevalence and persistence of most symptoms are lacking. Using an insurance claims database, we identified patients with coccidioidomycosis diagnoses in the United States during 2017-2023. We assessed prevalence of associated symptoms from 6 months before to 1 year after first diagnosis code (index date) and compared post-index date prevalence to baseline (within 6 to 4 months before index date). Among 2,640 patients, cough (20.8%), dyspnea (13.0%), and fatigue (8.8%) were the most common symptoms at index date. Dyspnea and erythema nodosum were elevated 3-6 months post-index date (p<0.03), and fatigue, headache, joint pain, and weakness were elevated 9-12 months post-index date cEmerging infectious diseases38-44https://www.ebi.ac.uk/biostudies/studies/S-EPMC12829482biostudies-literaturePersistence of Symptoms among Commercially Insured Patients with Coccidioidomycosis, United States, 2017-2023.PMC12829482Thompson GRWilliams SLToda MHennessee IBenedict KSmith DJfalsePersistence of Symptoms among Commercially Insured Patients with Coccidioidomycosis, United States, 2017-2023.Some patients with coccidioidomycosis experience prolonged respiratory and systemic symptoms. However, data on prevalence and persistence of most symptoms are lacking. Using an insurance claims database, we identified patients with coccidioidomycosis diagnoses in the United States during 2017-2023. We assessed prevalence of associated symptoms from 6 months before to 1 year after first diagnosis code (index date) and compared post-index date prevalence to baseline (within 6 to 4 months before index date). Among 2,640 patients, cough (20.8%), dyspnea (13.0%), and fatigue (8.8%) were the most common symptoms at index date. Dyspnea and erythema nodosum were elevated 3-6 months post-index date (p<0.03), and fatigue, headache, joint pain, and weakness were elevated 9-12 months post-index date c2025-01-01T00:00:00Z2025 Dec2026-06-06T21:18:12.031Z2026-06-05T03:11:40.606ZS-EPMC128294824157018210.3201/eid3114.250022