biostudies-literatureUnknownDe Santis FMinor ischemic strokes, usually defined as acute ischemic strokes with National Institutes of Health Stroke Scale score ≤5, account for over half of all cases and are often underestimated due to initially mild symptoms. Yet up to 30% of patients develop disability within 90 days, challenging the notion of a benign course. This guidance offers a pragmatic, scenario-based framework for acute minor ischemic stroke management, considering symptom severity (disabling versus nondisabling), eligibility for reperfusion, and presence of large vessel occlusion. Drawing from randomized trials, real-world evidence, and international guidelines, we examine therapeutic strategies, including dual antiplatelet therapy with aspirin plus a P2Y₁₂ inhibitor, anticoagulation, intravenous thrombolysiStrokehttps://www.ebi.ac.uk/biostudies/studies/S-EPMC12829504biostudies-literatureAcute Treatment of Disabling and Nondisabling Minor Ischemic Stroke: Expert Guidance for Clinicians.PMC12829504Foschi MD'Anna LFischer UPontes-Neto OMTurc GKhatri PCoutts SBDe Santis FSandset ECTsivgoulis GSacco SNasreldein ANguyen TNfalseAcute Treatment of Disabling and Nondisabling Minor Ischemic Stroke: Expert Guidance for Clinicians.Minor ischemic strokes, usually defined as acute ischemic strokes with National Institutes of Health Stroke Scale score ≤5, account for over half of all cases and are often underestimated due to initially mild symptoms. Yet up to 30% of patients develop disability within 90 days, challenging the notion of a benign course. This guidance offers a pragmatic, scenario-based framework for acute minor ischemic stroke management, considering symptom severity (disabling versus nondisabling), eligibility for reperfusion, and presence of large vessel occlusion. Drawing from randomized trials, real-world evidence, and international guidelines, we examine therapeutic strategies, including dual antiplatelet therapy with aspirin plus a P2Y₁₂ inhibitor, anticoagulation, intravenous thrombolysi2025-01-01T00:00:00Z2025 Dec2026-06-06T22:05:18.109Z2026-06-05T03:12:21.5ZS-EPMC128295044137658710.1161/STROKEAHA.125.053504