biostudies-literatureUnknown21(1)Matwiejczuk S<h4>Background</h4>Glaucoma is an optic neuropathy characterized by progressive retinal ganglion cells degeneration and associated visual field defects. Although elevated intraocular pressure is a major risk factor, glaucoma can also develop in individuals with statistically normal intraocular pressure, implying alternative mechanisms such as neurotrophins deprivation and primary lateral geniculate nucleus injury. These mechanisms may suggest a neurodegenerative aspect of the disease.<h4>Methods</h4>In this study, we evaluated 15 patients with bilateral early-stage normal-tension glaucoma, 10 with bilateral early-stage high-tension glaucoma, and 15 age-matched controls. All participants underwent standard ophthalmic examinations, including visual field testing and retinal nerve fiber layerPloS onee0341306https://www.ebi.ac.uk/biostudies/studies/S-EPMC12829933biostudies-literatureComparison of volumes of brain areas in patients with bilateral early high-tension and normal-tension glaucoma in 7 Tesla MRI.PMC12829933Matwiejczuk SKosior-Jarecka EToborek KWrobel-Dudzinska DPietura RMidura MZarnowski TNiedzialek AfalseComparison of volumes of brain areas in patients with bilateral early high-tension and normal-tension glaucoma in 7 Tesla MRI.<h4>Background</h4>Glaucoma is an optic neuropathy characterized by progressive retinal ganglion cells degeneration and associated visual field defects. Although elevated intraocular pressure is a major risk factor, glaucoma can also develop in individuals with statistically normal intraocular pressure, implying alternative mechanisms such as neurotrophins deprivation and primary lateral geniculate nucleus injury. These mechanisms may suggest a neurodegenerative aspect of the disease.<h4>Methods</h4>In this study, we evaluated 15 patients with bilateral early-stage normal-tension glaucoma, 10 with bilateral early-stage high-tension glaucoma, and 15 age-matched controls. All participants underwent standard ophthalmic examinations, including visual field testing and retinal nerve fiber layer2026-01-01T00:00:00Z20262026-06-06T22:07:32.062Z2026-06-05T03:12:14.383ZS-EPMC128299334157614510.1371/journal.pone.0341306