{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Adao I"],"funding":["NIDDK NIH HHS"],"pagination":["341-348"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12830046"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(3)"],"pubmed_abstract":["<h4>Purpose of review</h4>The purpose of the article is to review treatment options for patients with AIH for whom first-line therapy is not successful. We outline recommended approaches for providers and new therapies on the horizon.<h4>Recent findings</h4>Budesonide, while advantageous in some respects, may not be as effective as predniso(lo)ne. Mycophenolate mofetil is most effective in the setting of azathioprine intolerance and less effective when the response to azathioprine has been inadequate. Infliximab is the biologic agent with the most evidence for use in AIH. Clinical trials studying interleukin 2, regulatory T cells, inhibitors of BAFF signaling, and immunoproteasome inhibitors have been initiated but more research is needed, particularly in Black people, Indigenous people, a"],"journal":["Current hepatology reports"],"pubmed_title":["AIH Therapy: Beyond First‑Line."],"pmcid":["PMC12830046"],"funding_grant_id":["R21 DK127275"],"pubmed_authors":["Adao I","Klepper A","Tana M"],"additional_accession":[]},"is_claimable":false,"name":"AIH Therapy: Beyond First‑Line.","description":"<h4>Purpose of review</h4>The purpose of the article is to review treatment options for patients with AIH for whom first-line therapy is not successful. We outline recommended approaches for providers and new therapies on the horizon.<h4>Recent findings</h4>Budesonide, while advantageous in some respects, may not be as effective as predniso(lo)ne. Mycophenolate mofetil is most effective in the setting of azathioprine intolerance and less effective when the response to azathioprine has been inadequate. Infliximab is the biologic agent with the most evidence for use in AIH. Clinical trials studying interleukin 2, regulatory T cells, inhibitors of BAFF signaling, and immunoproteasome inhibitors have been initiated but more research is needed, particularly in Black people, Indigenous people, a","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-06-16T07:31:02.548Z","creation":"2026-06-16T03:10:17.997Z"},"accession":"S-EPMC12830046","cross_references":{"pubmed":["41585412"],"doi":["10.1007/s11901-024-00657-4"]}}