{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(2)"],"submitter":["Chatzikonstantinou T"],"pubmed_abstract":["<h4>Abstract</h4>Central nervous system involvement (CNSi) of chronic lymphocytic leukemia (CLL) is a rare condition with no consensus on diagnostic criteria and limited evidence for management and outcome. Here, we report an international, multicenter, retrospective study conducted by the European Research Initiative on CLL. The study defined CNSi of CLL by the following: (1) detection of CLL cells in the cerebrospinal fluid or confirmation of CLL infiltration of the CNS based on a tissue biopsy, (2) clinical or radiographic evidence of neurologic disease, and (3) the absence of other explanations for the neurologic findings. A total of 48 patients from 26 centers in 15 countries met all 3 diagnostic criteria of CLL-CNSi. Median age at diagnosis of CNSi was 64 years. Most patients were ma"],"journal":["Blood advances"],"pagination":["428-438"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12830125"],"repository":["biostudies-literature"],"pubmed_title":["Central nervous system involvement in CLL: an international retrospective study by ERIC, the European Research Initiative on CLL."],"pmcid":["PMC12830125"],"pubmed_authors":["Gutwein O","Talimtzi P","Niemann CU","Ahn IE","Martino EA","Garcia Vela JA","Pfister V","Doubek M","Nikitin E","Kotsianidis I","Tranidou A","Minga E","Marquet J","Jablonowska-Babij P","Wasik-Szczepanek E","McAuley C","Stavroyianni N","Gentile M","Wrobel T","Cerutti A","Espinet B","Enggaard L","Jaksic O","Shvidel L","Savas EM","Vazquez EG","Brown JR","Mikhaleva M","Brieghel C","Mosquera C","Josefsson P","Arrais-Rodrigues C","Moia R","Koren-Michowitz M","Anderson MA","Davids MS","Herishanu Y","Vrachiolias G","Besikli-Dimou S","Scarfo L","Simkovic M","Mela Osorio MJ","Chatzidimitriou A","Lista E","Ghia P","Pavlovsky MA","Stamatopoulos K","Chatzikonstantinou T","Kislova M","Cellini A","Kalicinska E","Visentin A","Sever M","Ferrer-Lores B","Papangelou C","Yagcı M","Gaidano G"],"additional_accession":[]},"is_claimable":false,"name":"Central nervous system involvement in CLL: an international retrospective study by ERIC, the European Research Initiative on CLL.","description":"<h4>Abstract</h4>Central nervous system involvement (CNSi) of chronic lymphocytic leukemia (CLL) is a rare condition with no consensus on diagnostic criteria and limited evidence for management and outcome. Here, we report an international, multicenter, retrospective study conducted by the European Research Initiative on CLL. The study defined CNSi of CLL by the following: (1) detection of CLL cells in the cerebrospinal fluid or confirmation of CLL infiltration of the CNS based on a tissue biopsy, (2) clinical or radiographic evidence of neurologic disease, and (3) the absence of other explanations for the neurologic findings. A total of 48 patients from 26 centers in 15 countries met all 3 diagnostic criteria of CLL-CNSi. Median age at diagnosis of CNSi was 64 years. Most patients were ma","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T22:07:45.175Z","creation":"2026-06-05T03:12:15.883Z"},"accession":"S-EPMC12830125","cross_references":{"pubmed":["41135013"],"doi":["10.1182/bloodadvances.2025017755"]}}