biostudies-literatureUnknown10(1)Cabre HE<h4>Background</h4>Total daily energy expenditure (TDEE) is vital for energy balance and cardiometabolic health, yet its trajectory across the lifespan, particularly in females, remains poorly understood.<h4>Objectives</h4>We sought to examine the effects of aging and sex on body composition and TDEE.<h4>Methods</h4>In a cross-sectional analysis of data from research centers across 9 European Countries and the United States from the International Atomic Energy Agency database, TDEE and body composition measures of 2326 participants (1560W/766M; 50.7 ± 12 .6 y) were stratified across age groups: young (30-39 y; YOUNG), middle-aged (40-54 y; MID), and old (55-70 y; OLD). Doubly labeled water was used to estimate TDEE and fat-free mass (FFM). Fat mass (FM) was calculated as the difference betCurrent developments in nutrition107614https://www.ebi.ac.uk/biostudies/studies/S-EPMC12830153biostudies-literatureSex Differences in Measures of Energy Expenditure and Body Composition in Young, Middle-Aged, and Older Adults.PMC12830153Arab LHu SRedman LMRavussin EVerbunt JACooper RKushner RFGurven MColbert LHWood BMLoechl CUBeyl RSchuit AJSagayama HRood JMarlatt KLUrlacher SSJoosen AMValencia MESardinha LBSilva AMFernandez-Verdejo RReynolds RMMurphy-Alford AJKriengsinyos WBonomi AGAnderson LJKatzmarzyk PPrentice RLLuke AHCasper RDeb SYamada YLessan NBovet PKraus WECabre HEGillingham MPontzer HAinslie PNMorehen JCCamps SGBouten CVWong WWKimura MButte NFAleman-Mateo HSchoeller DAClose GLAndersen LFDas SKMartin CKRaichlen DAVan Etten LMBedu-Addo KForrester TMorton JPSpeakman JRRoberts SBYoshida TBrage SBuchowski MSMatsiko EWesterterp KRLof MKempen KPHambly CWilson GZhang XNeuhouser MLRacette SBCooper JAGoris AHMedin ACfalseSex Differences in Measures of Energy Expenditure and Body Composition in Young, Middle-Aged, and Older Adults.<h4>Background</h4>Total daily energy expenditure (TDEE) is vital for energy balance and cardiometabolic health, yet its trajectory across the lifespan, particularly in females, remains poorly understood.<h4>Objectives</h4>We sought to examine the effects of aging and sex on body composition and TDEE.<h4>Methods</h4>In a cross-sectional analysis of data from research centers across 9 European Countries and the United States from the International Atomic Energy Agency database, TDEE and body composition measures of 2326 participants (1560W/766M; 50.7 ± 12 .6 y) were stratified across age groups: young (30-39 y; YOUNG), middle-aged (40-54 y; MID), and old (55-70 y; OLD). Doubly labeled water was used to estimate TDEE and fat-free mass (FFM). Fat mass (FM) was calculated as the difference bet2026-01-01T00:00:00Z2026 Jan2026-06-16T04:45:46.754Z2026-06-16T03:06:36.358ZS-EPMC128301534158312810.1016/j.cdnut.2025.107614