biostudies-literatureUnknown11(3)Van de Perre E<h4>Introduction</h4>There is limited real-world data on the effectiveness of combined prophylactic measures to prevent recurrent kidney stone formation.<h4>Methods</h4>This single-center retrospective study evaluated the effect of combined, patient-tailored prophylaxis on metabolic risk factors, urinary crystallization risk indices, and renal colic and urological intervention rates in a real-life clinical setting.<h4>Results</h4>Four hundred ninety patients with nephrolithiasis (NL) with a median follow-up of 12.8 months were evaluated. After the introduction of prophylaxis, the main metabolic risk factors, namely urinary volume, oxalate, calcium, and citrate excretion improved significantly in patients presenting the specific risk factor at baseline (+ 653 ml/24 h for urinary volume, - 1Kidney international reports103719https://www.ebi.ac.uk/biostudies/studies/S-EPMC12830155biostudies-literatureTailored Kidney Stone Prevention Improves Metabolic Risk Factors and Reduces Renal Colic Rate.PMC12830155Van Hulle FDe Clerck DBazin DTielemans CLetavernier ERobberechts TDaudon MFrancois KJanssens PAllamani MPipeleers LWissing KMJanssens FVCools WVan de Perre EfalseTailored Kidney Stone Prevention Improves Metabolic Risk Factors and Reduces Renal Colic Rate.<h4>Introduction</h4>There is limited real-world data on the effectiveness of combined prophylactic measures to prevent recurrent kidney stone formation.<h4>Methods</h4>This single-center retrospective study evaluated the effect of combined, patient-tailored prophylaxis on metabolic risk factors, urinary crystallization risk indices, and renal colic and urological intervention rates in a real-life clinical setting.<h4>Results</h4>Four hundred ninety patients with nephrolithiasis (NL) with a median follow-up of 12.8 months were evaluated. After the introduction of prophylaxis, the main metabolic risk factors, namely urinary volume, oxalate, calcium, and citrate excretion improved significantly in patients presenting the specific risk factor at baseline (+ 653 ml/24 h for urinary volume, - 12026-01-01T00:00:00Z2026 Mar2026-06-13T05:17:24.344Z2026-06-13T03:08:53.809ZS-EPMC128301554158426810.1016/j.ekir.2025.103719