{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ding M"],"funding":["Kunshan Traditional Chinese Medicine Science and Technology Development Fund Project","Kunshan Social Development Project","Nanjing University of Chinese Medicine Natural Science Foundation Project","Key Projects of Jiangsu Provincial Science","Suzhou Clinical Key Disease Diagnosis and Treatment Project"],"pagination":["51"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12831259"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["Background
Non-alcoholic fatty liver disease (NAFLD), often accompanied by insulin resistance, obesity, and hyperlipidemia, is a challenging metabolic disorder to treat. Ge-Lian Qi-Shen Decoction, a traditional Chinese herbal formula, has been clinically used to alleviate symptoms associated with NAFLD, but its underlying mechanisms remain unclear.Methods
A NAFLD model was established in C57BL/6J mice using a high-fat diet (HFD). The effects of 4-week GQD intervention at different doses on NAFLD-related symptoms were assessed using biochemical analyses, pathological sections, and oral glucose tolerance tests. ELISA and qPCR were employed to investigate the impact of GQD on serum GLP-1 levels and intestinal Gcg gene expression in NAFLD mice. The direct stimulatory effects of"],"journal":["Chinese medicine"],"pubmed_title":["Targeting G-protein-coupled receptors and gut microbiota: Ge-Lian Qi-Shen decoction elevates GLP-1 to combat non-alcoholic fatty liver disease."],"pmcid":["PMC12831259"],"funding_grant_id":["ZD202425","LCZX202229","XZR2024193","KS2233","KZYY2209"],"pubmed_authors":["Peng H","Guo M","Luo Z","Zhang Z","Shan J","Xiao Z","Xu R","Xu C","Hou X","Ding M"],"additional_accession":[]},"is_claimable":false,"name":"Targeting G-protein-coupled receptors and gut microbiota: Ge-Lian Qi-Shen decoction elevates GLP-1 to combat non-alcoholic fatty liver disease.","description":"Background
Non-alcoholic fatty liver disease (NAFLD), often accompanied by insulin resistance, obesity, and hyperlipidemia, is a challenging metabolic disorder to treat. Ge-Lian Qi-Shen Decoction, a traditional Chinese herbal formula, has been clinically used to alleviate symptoms associated with NAFLD, but its underlying mechanisms remain unclear.Methods
A NAFLD model was established in C57BL/6J mice using a high-fat diet (HFD). The effects of 4-week GQD intervention at different doses on NAFLD-related symptoms were assessed using biochemical analyses, pathological sections, and oral glucose tolerance tests. ELISA and qPCR were employed to investigate the impact of GQD on serum GLP-1 levels and intestinal Gcg gene expression in NAFLD mice. The direct stimulatory effects of","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-13T05:17:32.251Z","creation":"2026-06-13T03:08:38.203Z"},"accession":"S-EPMC12831259","cross_references":{"pubmed":["41580820"],"doi":["10.1186/s13020-025-01305-9"]}}