{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hao Y"],"funding":["Central Guidance Fund for Science and Technology Development","Fundamental Research Funds for the Central Universities","National Natural Science Foundation of China","Open Funds of the State Key Laboratory of Chemo and Biosensing, Hunan University"],"pagination":["68"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12831401"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["Carbon quantum dot (CQD)-based nanozymes have attracted growing interest for advanced biomedical applications owing to their superior catalytic activity, photostability, and biocompatibility. However, the rational design of a multifunctional nanoplatform that integrates active targeting, multimodal imaging, and synergistic therapy through a green and sustainable approach remains highly challenging. Herein, we report a facile and environmentally benign solvothermal strategy for the synthesis of ruthenium-doped CQD nanozymes (Ru-CQDs) functionalized with AS1411 aptamers and polyethylene glycol (PEG), denoted as Ru-CQDs-AS1411@PEG. This eco-friendly synthesis avoids toxic reagents and harsh conditions while yielding highly uniform and biocompatible nanozymes. The obtained Ru-CQDs-AS1411@PEG e"],"journal":["Journal of nanobiotechnology"],"pubmed_title":["Aptamer-engineered NIR-II Ru-doped carbon quantum dot nanozyme for photoacoustic imaging-guided synergistic photothermal and catalytic cancer therapy."],"pmcid":["PMC12831401"],"funding_grant_id":["21705101, 22274090","2020JCPT02","2025-0937-13","YDZJSX2021A004, YDZJSX2022C002","22204102"],"pubmed_authors":["Li C","Shuang S","Ding D","Chen Y","Hao Y","Wang H","Wang Z","Dong C","Gong X"],"additional_accession":[]},"is_claimable":false,"name":"Aptamer-engineered NIR-II Ru-doped carbon quantum dot nanozyme for photoacoustic imaging-guided synergistic photothermal and catalytic cancer therapy.","description":"Carbon quantum dot (CQD)-based nanozymes have attracted growing interest for advanced biomedical applications owing to their superior catalytic activity, photostability, and biocompatibility. However, the rational design of a multifunctional nanoplatform that integrates active targeting, multimodal imaging, and synergistic therapy through a green and sustainable approach remains highly challenging. Herein, we report a facile and environmentally benign solvothermal strategy for the synthesis of ruthenium-doped CQD nanozymes (Ru-CQDs) functionalized with AS1411 aptamers and polyethylene glycol (PEG), denoted as Ru-CQDs-AS1411@PEG. This eco-friendly synthesis avoids toxic reagents and harsh conditions while yielding highly uniform and biocompatible nanozymes. The obtained Ru-CQDs-AS1411@PEG e","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T22:32:29.312Z","creation":"2026-06-06T03:10:32.852Z"},"accession":"S-EPMC12831401","cross_references":{"pubmed":["41422248"],"doi":["10.1186/s12951-025-03919-5"]}}