{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["110(1)"],"submitter":["Fritze MT"],"funding":["Technische Universität Bergakademie Freiberg"],"pubmed_abstract":["Bioleaching is an established process for sulfidic ores and is increasingly applied to the recycling of industrial residues. However, unlike ores, many residues like sludge contain inhibitory elements, among which fluoride poses a major challenge due to its toxicity toward acidophilic microorganisms even at low concentrations. This study systematically investigated fluoride tolerance in pure and mixed cultures of various acidophilic sulfur- and iron-oxidizing bacteria commonly used for bioleaching, including Acidithiobacillus spp., Leptospirillum spp., and Sulfobacillus thermosulfidooxidans. Fluoride toxicity was found to be substrate-dependent. During sulfur oxidation, A. thiooxidans displayed the highest fluoride tolerance (0.5 mM F⁻), whereas S. thermosulfidooxidans showed complete inhi"],"journal":["Applied microbiology and biotechnology"],"pagination":["32"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12831704"],"repository":["biostudies-literature"],"pubmed_title":["Fluoride toxicity and mitigation strategies in acidophilic bioleaching microorganisms."],"pmcid":["PMC12831704"],"pubmed_authors":["Hedrich S","Fritze MT"],"additional_accession":[]},"is_claimable":false,"name":"Fluoride toxicity and mitigation strategies in acidophilic bioleaching microorganisms.","description":"Bioleaching is an established process for sulfidic ores and is increasingly applied to the recycling of industrial residues. However, unlike ores, many residues like sludge contain inhibitory elements, among which fluoride poses a major challenge due to its toxicity toward acidophilic microorganisms even at low concentrations. This study systematically investigated fluoride tolerance in pure and mixed cultures of various acidophilic sulfur- and iron-oxidizing bacteria commonly used for bioleaching, including Acidithiobacillus spp., Leptospirillum spp., and Sulfobacillus thermosulfidooxidans. Fluoride toxicity was found to be substrate-dependent. During sulfur oxidation, A. thiooxidans displayed the highest fluoride tolerance (0.5 mM F⁻), whereas S. thermosulfidooxidans showed complete inhi","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T22:26:08.352Z","creation":"2026-06-06T03:07:53.485Z"},"accession":"S-EPMC12831704","cross_references":{"pubmed":["41578028"],"doi":["10.1007/s00253-025-13677-x"]}}