biostudies-literatureUnknown43(1)Taggi M<h4>Purpose</h4>To identify treatment-related factors influencing low oocyte maturation rates in standard ovarian stimulation (OS) cycles and patients' candidates for clinical studies on rescue-IVM.<h4>Methods</h4>Retrospective study including retrievals with ≥ 1 cumulus-oocyte-complex (COC; years: 2008-2022). The weighted-mean immaturityrate (19%) was defined in the whole dataset (N = 16,155). Variables associated with immaturity rates and warning limit (defined as weighted average + 2SD) were appraised among first retrievals with ≥ 5 COCs (N = 7962). Of the patients undergoing a first oocyte pick-up, 667 completed three retrieval cycles, enabling evaluation of the true prevalence of patients exceeding the immaturity rate warning threshold over multiple cycles.<h4>Results</h4>Factors inflJournal of assisted reproduction and genetics167-177https://www.ebi.ac.uk/biostudies/studies/S-EPMC12831772biostudies-literatureRates and risk factors of oocyte immaturity: toward personalized selection for rescue in vitro maturation.PMC12831772Coticchio GMaggiulli RTaggi MSoscia DMPetrone PAlbricci LRuffa AFiorentino GCapalbo ACimadomo DRienzi LInnocenti FCasciani VCermisoni GCZuccotti MVaiarelli AfalseRates and risk factors of oocyte immaturity: toward personalized selection for rescue in vitro maturation.<h4>Purpose</h4>To identify treatment-related factors influencing low oocyte maturation rates in standard ovarian stimulation (OS) cycles and patients' candidates for clinical studies on rescue-IVM.<h4>Methods</h4>Retrospective study including retrievals with ≥ 1 cumulus-oocyte-complex (COC; years: 2008-2022). The weighted-mean immaturityrate (19%) was defined in the whole dataset (N = 16,155). Variables associated with immaturity rates and warning limit (defined as weighted average + 2SD) were appraised among first retrievals with ≥ 5 COCs (N = 7962). Of the patients undergoing a first oocyte pick-up, 667 completed three retrieval cycles, enabling evaluation of the true prevalence of patients exceeding the immaturity rate warning threshold over multiple cycles.<h4>Results</h4>Factors infl2026-01-01T00:00:00Z2026 Jan2026-06-06T21:58:40.848Z2026-06-05T03:12:05.39ZS-EPMC128317724123900710.1007/s10815-025-03722-z