{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Y"],"funding":["National Natural Science Foundation of China","National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["944"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12831795"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["Copper-catalyzed azide-alkyne cycloaddition (CuAAC) is a pivotal strategy for joining two fragments, including bioactive moieties under mild conditions. In recent years, \"interrupted\" CuAAC reaction has emerged by intercepting copper triazolide intermediates, thereby significantly broadening the scope of these transformations. However, asymmetric transformations based on the interruption of copper triazolide intermediates have remained elusive. In this work, we present an efficient and mild approach that intercepts a copper triazolide intermediate with a cyclic diaryliodonium reagent, enabling a three-component coupling of the cyclic diaryliodonium species, an alkyne, and an azide under atroposelective control. This method constitutes an asymmetric interrupted CuAAC reaction and furnishes "],"journal":["Nature communications"],"pubmed_title":["Atroposelective interrupted CuAAC reaction using cyclic diaryliodoniums."],"pmcid":["PMC12831795"],"funding_grant_id":["22301291"],"pubmed_authors":["Li Y","Duan L","Gu Z","Yang S"],"additional_accession":[]},"is_claimable":false,"name":"Atroposelective interrupted CuAAC reaction using cyclic diaryliodoniums.","description":"Copper-catalyzed azide-alkyne cycloaddition (CuAAC) is a pivotal strategy for joining two fragments, including bioactive moieties under mild conditions. In recent years, \"interrupted\" CuAAC reaction has emerged by intercepting copper triazolide intermediates, thereby significantly broadening the scope of these transformations. However, asymmetric transformations based on the interruption of copper triazolide intermediates have remained elusive. In this work, we present an efficient and mild approach that intercepts a copper triazolide intermediate with a cyclic diaryliodonium reagent, enabling a three-component coupling of the cyclic diaryliodonium species, an alkyne, and an azide under atroposelective control. This method constitutes an asymmetric interrupted CuAAC reaction and furnishes ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T21:58:37.248Z","creation":"2026-06-05T03:12:04.851Z"},"accession":"S-EPMC12831795","cross_references":{"pubmed":["41580395"],"doi":["10.1038/s41467-026-68574-2"]}}