{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Almohammad K"],"funding":["SFB1506: \"Aging at Interfaces\" to H.J. and J.T.","CRC1279 : \"Exploiting the Human Peptidome for Novel Antimicrobial and Anticancer Agents\" to H.J.","S.V.","H.J.","Further project funding by the DFG was granted to S.V. and F.G.","J.T."],"pagination":["e70137"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12832068"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["56(1)"],"pubmed_abstract":["Glucocorticoids (GCs) regulate diverse physiological processes, comprising metabolism, immune responses, stress adaptation, and inflammation. Synthetic GCs are widely used for their powerful anti-inflammatory and immunosuppressive effects, in the treatment of autoimmune diseases, allergies, and inflammation. Here, we investigated the role of the glucocorticoid receptor (GR) in B cell development and survival using both B cell-specific GR-deficient mice and continuous in vivo GR agonist treatments. Deletion of the GR in B cells altered splenic B cell subpopulations, increasing follicular and CD21<sup>lo</sup> B cells and leading to the accumulation of IgM<sup>-</sup>/IgD<sup>-</sup> B cells. In vivo treatment with GR agonists, such as Dexamethasone (Dex) and Prednisolone (Pred), selectively"],"journal":["European journal of immunology"],"pubmed_title":["IgD-Expressing Mature B Cells Exhibit Enhanced Sensitivity to Glucocorticoid-Induced Cell Death."],"pmcid":["PMC12832068"],"funding_grant_id":["505870049","B03","497680553","B05","450627322","C05","326914434","537908488"],"pubmed_authors":["Setz CS","Alkhatib M","Almohammad K","Greulich F","Jumaa H","Tuckermann J","Young M","Vettorazzi S"],"additional_accession":[]},"is_claimable":false,"name":"IgD-Expressing Mature B Cells Exhibit Enhanced Sensitivity to Glucocorticoid-Induced Cell Death.","description":"Glucocorticoids (GCs) regulate diverse physiological processes, comprising metabolism, immune responses, stress adaptation, and inflammation. Synthetic GCs are widely used for their powerful anti-inflammatory and immunosuppressive effects, in the treatment of autoimmune diseases, allergies, and inflammation. Here, we investigated the role of the glucocorticoid receptor (GR) in B cell development and survival using both B cell-specific GR-deficient mice and continuous in vivo GR agonist treatments. Deletion of the GR in B cells altered splenic B cell subpopulations, increasing follicular and CD21<sup>lo</sup> B cells and leading to the accumulation of IgM<sup>-</sup>/IgD<sup>-</sup> B cells. In vivo treatment with GR agonists, such as Dexamethasone (Dex) and Prednisolone (Pred), selectively","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T22:26:09.231Z","creation":"2026-06-06T03:07:53.88Z"},"accession":"S-EPMC12832068","cross_references":{"pubmed":["41581071"],"doi":["10.1002/eji.70137"]}}