biostudies-literatureAlmohammad KSFB1506: "Aging at Interfaces" to H.J. and J.T.CRC1279 : "Exploiting the Human Peptidome for Novel Antimicrobial and Anticancer Agents" to H.J.S.V.H.J.Further project funding by the DFG was granted to S.V. and F.G.J.T.e70137https://www.ebi.ac.uk/biostudies/studies/S-EPMC12832068biostudies-literatureUnknown56(1)Glucocorticoids (GCs) regulate diverse physiological processes, comprising metabolism, immune responses, stress adaptation, and inflammation. Synthetic GCs are widely used for their powerful anti-inflammatory and immunosuppressive effects, in the treatment of autoimmune diseases, allergies, and inflammation. Here, we investigated the role of the glucocorticoid receptor (GR) in B cell development and survival using both B cell-specific GR-deficient mice and continuous in vivo GR agonist treatments. Deletion of the GR in B cells altered splenic B cell subpopulations, increasing follicular and CD21^lo B cells and leading to the accumulation of IgM^-/IgD^- B cells. In vivo treatment with GR agonists, such as Dexamethasone (Dex) and Prednisolone (Pred), selectivelyEuropean journal of immunologyIgD-Expressing Mature B Cells Exhibit Enhanced Sensitivity to Glucocorticoid-Induced Cell Death.PMC12832068505870049B03497680553B05450627322C05326914434537908488Setz CSAlkhatib MAlmohammad KGreulich FJumaa HTuckermann JYoung MVettorazzi SfalseIgD-Expressing Mature B Cells Exhibit Enhanced Sensitivity to Glucocorticoid-Induced Cell Death.Glucocorticoids (GCs) regulate diverse physiological processes, comprising metabolism, immune responses, stress adaptation, and inflammation. Synthetic GCs are widely used for their powerful anti-inflammatory and immunosuppressive effects, in the treatment of autoimmune diseases, allergies, and inflammation. Here, we investigated the role of the glucocorticoid receptor (GR) in B cell development and survival using both B cell-specific GR-deficient mice and continuous in vivo GR agonist treatments. Deletion of the GR in B cells altered splenic B cell subpopulations, increasing follicular and CD21^lo B cells and leading to the accumulation of IgM^-/IgD^- B cells. In vivo treatment with GR agonists, such as Dexamethasone (Dex) and Prednisolone (Pred), selectively2026-01-01T00:00:00Z2026 Jan2026-06-06T22:26:09.231Z2026-06-06T03:07:53.88ZS-EPMC128320684158107110.1002/eji.70137